A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis

L Chen, M De Menna, A Groenewoud, GN Thalmann… - Oncogene, 2020 - nature.com
… by viable cell sorting display CSCs characteristics [3]. Although the features of prostate CSCs
… In the end we detected if Activin-signaling controls PCa cell invasion. PC-3M-Pro4 tumor …

Activin B and activin C have opposing effects on prostate cancer progression and cell growth

KL Reader, S John-McHaffie, S Zellhuber-McMillan… - Cancers, 2022 - mdpi.com
… growth of PNT1A cells and decreased growth of PC3 cells. In conclusion, increased activin
B and decreased activin C expression is associated with increasing prostate tumor grade and …

[PDF][PDF] The Effects of Activin B and Activin C on the Growth and Migration of Prostate Cancer Cells

S John-McHaffie - 2022 - ourarchive.otago.ac.nz
… improve prostate cancer outcomes. This research studied activin B and activin C and tested
the hypotheses that these activins alter growth and migration in the healthy and cancerous …

Activin and BMP Signalling in Human Testicular Cancer Cell Lines, and a Role for the Nucleocytoplasmic Transport Protein Importin-5 in Their Crosstalk

K Radhakrishnan, M Luu, J Iaria, JM Sutherland… - Cells, 2023 - mdpi.com
… A balance between activin and BMP signalling may influence TGCT emergence … cell
line models of seminoma (TCam-2) and non-seminoma (NT2/D1). Activin A- and BMP4-regulated

Activin A Modulates Betaglycan Shedding via the ALK4-SMAD3-Dependent Pathway in Endometriotic Cells

AN Mwaura, MA Riaz, JB Maoga, E Mecha… - Biomolecules, 2022 - mdpi.com
… of BG on the viability and proliferation of endometriotic epithelial cells and found no effects at
the … a viability above 98% indicating that the recombinant BG had no effects on cell viability (…

ΔNp63 overexpression promotes oral cancer cell migration through hyperactivated Activin A signaling

D Mundhe, R Mishra, S Basu, S Dalal, S Kumar… - Experimental Cell …, 2023 - Elsevier
… we next analyzed the cell viability, invasive and migratory potential of AW8507 and SCC040
… focal adhesion, cell adhesion, ECM organization pathways to be possibly regulated by p63. …

[HTML][HTML] Activin receptors in human cancer: Functions, mechanisms, and potential clinical applications

R Du, L Wen, M Niu, L Zhao, X Guan, J Yang… - Biochemical …, 2024 - Elsevier
… of activin receptors have … activin receptors in cancer. Thus, this review aimed to consolidate
existing knowledge concerning activin receptors, with a primary emphasis on their signaling

Dual roles of the activin signaling pathway in pancreatic cancer

W Qiu, CY Kuo, Y Tian, GH Su - Biomedicines, 2021 - mdpi.com
Activin-βB-deficient mice were viable but with defects in eyelid formation; female mice …
For instance, activin can increase the expression of a neural cell adhesion molecule (NCAM…

Cell plasticity and prostate cancer: The role of epithelial–mesenchymal transition in tumor progression, invasion, metastasis and cancer therapy resistance

S Papanikolaou, A Vourda, S Syggelos, K Gyftopoulos - Cancers, 2021 - mdpi.com
epithelial markers and downregulation of mesenchyme markers, which in turn allows for
tumor cell adhesion … suppressed the viability and proliferation in the PCa cell lines DU145 and …

Activin A in mammalian physiology

E Bloise, P Ciarmela, C Dela Cruz… - Physiological …, 2019 - journals.physiology.org
… how activin A is regulated and whether it is implicated in the genesis of … prostatic disease.
We do not know the age-specific pattern of activin subunits, receptors, and postreceptor signal