… The 2016 revision of the WHO classification of hematologic malignancies [8] distinguishes
nine AML … levels of a selected panel of genes as well as translocations from mRNAseq data. …

… Additionally, eight new provisional entities are added to the T-ALL subclassification. The
clinical implications of the new entities are discussed, as are practical approaches to the use of …

… acute myeloid leukemia (AML). Here, we show in murine and human models of AML that,
upon perturbation of endogenous expression of the lineage-determining transcription factor PU…

… TCR-C4 ) to minimize graft-versus-host disease risk and enhance transferred T cell
survival 7,8 , and infused these cells prophylactically post-HCT into 12 patients (NCT01640301). …

… The lncRNA CASC15 (cancer susceptibility candidate 15) is upregulated in pediatric
RUNX1-rearranged AML, with the highest level found in AML with the t(8;21) translocation and is …

… Only one previously reported patient [Citation24] in this analysis had t(8;14)(q24;q32); thus
… t(8;14) (q24;q32) is extremely rare. In the few reports available in the literature, AML with t(8;…

… tumor-specific T cells can be … T cells from large numbers of PBMCs from 6 HLA-A*02:01–positive
healthy individuals (Table 2). A variable number of 8 to 55 tetramer-positive CD8 + T …

… Acute myeloid leukemia (AML) comprises a heterogeneous group of … This entity
includes AML with balanced translocation/ … AML with balanced translocations include t(8;21)(q22;q22.1); …

… Hereby, they were able to define in addition to 8 established AML subsets three new … with
CAR T-cells, since preclinical analyses revealed a synergistical effect of FLT3 targeting CAR T-…

… Indeed, children with t(8;21) seem to had benefited from higher cumulative doses of …
therapy for patients without CNS leukemia at the time of diagnosis and at least 8 doses (4 weekly …