… of myeloid neoplasms originally in 2008 and again in 2016 [8… subsequent, larger studies
have demonstrated t(8;21) to be a … 7, trisomy 8 and KMT2A translocations (involving 11q23) are …

… fusion partners, was among the genes with unique expression profile in t(8;21), which
suggested similar mechanism of pathogenesis with t(6;11). High expression of NT5E, observed in …

… in acute myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout
the disease course, and highly leukemia … High-avidity CD8 + T cell clones isolated from …

… of young patients with de novo acute myeloid leukemia (AML) was decided combining …
MRD-negative) plus 27 IR patients (8%) with no leukemia-associated phenotype, for a total of 177 …

… A translocation between chromosomes 8 and 21 [t(8;21)(q22;q22)] underlies the RUNX1/RUNX1T1
fusion. Both rearrangements disrupt CBF function, leading to a block of …

… majority of leukemic blasts [54, 55], and KIT mutations, most commonly affecting exons 8 and
… Recently, the targeted high-throughput sequencing in 331 patients with t(8;21), which leads …

… with the core binding factor gene rearrangements, t(8;21) or inv(16)/t(16;16), both have
relatively favorable outcomes. However, data from the CALGB and AML-SG study groups and the …

… resulted in poorer outcomes, particularly in patients with t(8;21). One multicenter study that
… ) at codon 816 (TKD 816 ) in patients with t(8;21) was associated with a significantly higher …

… CXCR4 inhibition prolongs the survival of T-ALL burdened mice,8 and promotes mobilization
and apoptosis of AML cells.9-11 CXCR4 antagonists in combination with chemotherapy …

Acute myeloid leukaemia (AML) incidence is age dependent, rising markedly in patients
aged! 60 years. Ageing of the European population may therefore contribute to the reported …