… Adaptive changes in pancreatic beta-cells involve hyperplasia, hypertrophy and increased
secretory activity in both humans … as part of the pancreas adaptive response, we performed an …

… pancreatic α-cells respond to pregnancy and their contribution to maternal metabolic
adaptation. … showed that pregnancy induced a significant increase of α-cell mass by promoting α-…

… Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human
pregnancy. Diabetologia 2010; 53(10): 2167-76. http://dx.doi.org/10.1007/s00125-010-1809-6 …

… of pregnancy. In preparation for the increased demand for insulin, adaptive changes occur in
the endocrine pancreas in … the fractional α-cell area (sum of all glucagon-expressing areas …

… direct implications for β cell function, turnover, and regeneration. … 13 (CS13, ~ 6.5-week
gestation) in humans is marked by the … or failed adaptation to increased β cell metabolic workload …

… β-cell function and survival. Here, we review calcium dynamics in islets in response to
pregnancy-induced changes in hormones and signaling molecules, and how these changes may …

… islet beta-cell adaptation in normal pregnancy has … pregnant (gestational day 11, G11) and
late pregnant (gestational day 19, G19) Sprague-Dawley rats. The expression of key beta-cell …

… During pregnancy the maternal pancreatic islets of Langerhans undergo adaptive changes
to … , suggesting a role in modulating the islet adaptation to pregnancy. In the present study we …

… regarding the adaptive changes of β cells during pregnancy is … cell turnover and area in
human pregnancy (2, 3), we report the presence of endocrine differentiation markers in pancreas …

… to the adaptive changes in β-cell … β-cell mass in human islets is controversial and inconclusive.
If the lactogenic hormones do play a key role in the islet adaptation to human pregnancy, …