… Adeno-associated virus (AAV)-mediated gene transfer is an … normal and damaged adult and
neonatal mouse utricles, which … , dual-AAV vectors with multiple target genes may be used. …

… The homozygous mice were bred together based on their normal fertility. The WT C57BL/6J …
) system with primers and probes targeting the promoter sequences of the transgene …

… , such as noise trauma, … target cells, making AAV serotypes valuable cell-targeting research
tools [34]. Recently, a publication has summarized AAV capsid transduction into the mouse …

… Gene therapy targeting these genes could potentially benefit … However, the facial nerve
covering the utricle region makes this … The safety and effectiveness of gene therapy in mouse …

… , resulting in surgical trauma and postoperative hearing damage for these aforementioned
routes. … In utricle, AAV8 showed no transduction signal and AAV9 targeted scattered VHCs, in …

… used adeno-associated virus (AAV) for gene delivery. AAV is … mouse utricles in vivo (Fig. 3,
Supplementary Table 1). The … as the targeted cell type in inner ear gene therapy studies, the …

… affects hair cell regeneration, we cultured adult mouse utricle, lesioned hair cells with the …
Adeno-associated virus-mediated gene transfer targeting normal and traumatized mouse utricle…

… adeno-associated virus (AAV) serotype 8 vector of two different titers to overexpress Atoh1
in the injured utricles of adult mice. … By contrast, virus-mediated overexpression can last for a …

… technologies such as adeno-associated virus (AAV) vectors, to deliver nucleic acid to target
cells in … An injection into the utricle would likely deliver to endolymph. With injection into the …

… This deficiency in effective targeting of SGNs limits the … Among these, viral vectors, particularly
adeno-associated … the endolymphatic sac and the utricle are two additional routes that …