… essential for prediction of toxic responses. This review provides an overview of drug-induced
injuries to the kidney, details on relevant and translational biomarkers, and advances in 3D …

… for predicting toxic reactions. This article reviews the mechanism of … models (in vivo and in
vitro models), and the research … use of advanced in vitro 3D models of kidney, kidney–liver, or …

… and the different in vitro and in vivo models used for prediction of the risk of drug induced
renal injury by … Advances in the experimental models for kidney demonstrate promise for the …

… of drug-induced nephrotoxicity, classes of nephrotoxic drugs, … Finally, it also highlights some
of the recent advancements in … to assist in the prediction of drug-induced toxicities. Over the …

… currently available in vitro models are capable of successfully predicting safety outcomes in
… Advanced in vitro models identified in this study and their characteristics are presented in …

… Here, we discuss how advanced culture models, including modified cell … in predicting
drug-induced nephrotoxicity and will be discussed in the next section on advanced in vitro models. …

… developed a murine 3D kidney organoid toxicity ex vivo model fulfilling many functional drug
… that this parameter offers better predictive value for nephrotoxicity in the 3D ex vivo kidney …

… the nephrotoxic potential of chemicals in early stage is quite important and useful for reducing
the failure of drug development. The in vivo test for drug induced nephrotoxicity evaluation …

… AKI can be explained by drug-induced nephrotoxicity in over 20% … early stage predictive
biomarkers of kidney disease, few … that new strategies are paramount for advances in this area. …

… advanced technologies and techniques to develop personalized and precise approaches for
predicting… of accurate and predictive 3D models for drug-induced nephrotoxicity testing and …