[HTML][HTML] Tolerability of maintenance olaparib in newly diagnosed patients with advanced ovarian cancer and a BRCA mutation in the randomized phase III SOLO1 trial
N Colombo, K Moore, G Scambia, A Oaknin… - Gynecologic …, 2021 - Elsevier
… Eligible patients were randomized to olaparib tablets 300 mg twice … Adverse events (AEs)
should be manageable over time and not … therapy in BRCA-mutated advanced ovarian cancer …
should be manageable over time and not … therapy in BRCA-mutated advanced ovarian cancer …
Sharing real-world experiences to optimize the management of olaparib toxicities: a practical guidance from an Italian expert panel
D Lorusso, A Bologna, SC Cecere, E De Matteis… - 2020 - Springer
… DNA double-strand break repair in BRCA mutated (mut) cancers [… olaparib (capsules)
compared with placebo [7, 8], olaparib … the formulation administered, adverse events (AEs) were of …
compared with placebo [7, 8], olaparib … the formulation administered, adverse events (AEs) were of …
[HTML][HTML] Olaparib tolerability and common adverse-event management in patients with metastatic castration-resistant prostate cancer: Further analyses from the …
G Roubaud, M Özgüroğlu, N Penel… - European Journal of …, 2022 - Elsevier
… alterations in DNA repair genes. To facilitate continued … common adverse events (AEs)
and events of special interest. … Alternatively, patients could also take olaparib tablets with a …
and events of special interest. … Alternatively, patients could also take olaparib tablets with a …
Olaparib: A review as first-line maintenance therapy in advanced ovarian cancer
J Paik - Targeted Oncology, 2021 - Springer
… AEs occurred in 49% and 43% of the olaparib plus bevacizumab and placebo plus bevacizumab
groups, and SAEs in 24% of both groups. AEs … manage adverse reactions to olaparib [9…
groups, and SAEs in 24% of both groups. AEs … manage adverse reactions to olaparib [9…
[HTML][HTML] Maintenance olaparib rechallenge in patients with platinum-sensitive relapsed ovarian cancer previously treated with a PARP inhibitor (OReO/ENGOT-ov38) …
E Pujade-Lauraine, F Selle, G Scambia, B Asselain… - Annals of …, 2023 - Elsevier
… 2 : 1 to maintenance olaparib tablets 300 mg twice daily or … non-BRCA-mutated cohort
were randomized to olaparib and … achieved without detrimental effects on patients’ HRQoL or …
were randomized to olaparib and … achieved without detrimental effects on patients’ HRQoL or …
[HTML][HTML] Cost-effectiveness of olaparib versus routine surveillance in the maintenance setting for patients with BRCA-mutated advanced ovarian cancer after response …
… -up of 41 months, patients treated with olaparib had a 70% … , and adverse events (AEs) were
consistent with olaparib's … of olaparib tablets as a maintenance monotherapy in patients who …
consistent with olaparib's … of olaparib tablets as a maintenance monotherapy in patients who …
Maintenance treatment for recurrent ovarian carcinoma–Evidence supporting the efficacy and safety of PARP inhibitors
RL Coleman, JA Ledermann - European Oncology and …, 2019 - discovery.ucl.ac.uk
… Study 19 was a randomised, Phase 2 evaluation of olaparib capsules (400 mg BID) used
as … The adverse event profile was consistent with the known toxic effects of olaparib. These …
as … The adverse event profile was consistent with the known toxic effects of olaparib. These …
Manage wisely: poly (ADP-ribose) polymerase inhibitor (PARPi) treatment and adverse events
A Madariaga, V Bowering, S Ahrari, AM Oza… - International Journal of …, 2020 - ijgc.bmj.com
… the combination of olaparib (300 mg, tablets twice daily) and … Table 3 summarizes adverse
events in PARPi maintenance … in patients (pts) with advanced triple-negative breast cancer or …
events in PARPi maintenance … in patients (pts) with advanced triple-negative breast cancer or …
Olaparib maintenance monotherapy in asian patients with platinum-sensitive relapsed ovarian cancer: phase III trial (L-MOCA)
Q Gao, J Zhu, W Zhao, Y Huang, R An, H Zheng… - Clinical Cancer …, 2022 - AACR
… with high-grade epithelial PSR ovarian cancer received oral olaparib 300 mg (tablet … in
terms of adverse events (AE) and serious AEs, laboratory analyses, and vital signs. AEs were …
terms of adverse events (AE) and serious AEs, laboratory analyses, and vital signs. AEs were …
[HTML][HTML] Olaparib in the therapy of advanced ovarian cancer: first real world experiences in safety and efficacy from China
J Ni, X Cheng, R Zhou, X Xu, W Guo… - Journal of Ovarian …, 2019 - Springer
… showed that Olaparib maintenance therapy significantly … with no BRCA-mutated or
BRCA-mutated platinum-sensitive … adverse events and short-term effects of Olaparib for patients …
BRCA-mutated platinum-sensitive … adverse events and short-term effects of Olaparib for patients …