Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus

Y Wu, S Bottes, R Fisch, C Zehnder, JD Cole, GA Pilz… - Nature Aging, 2023 - nature.com
… 2j), consistent with an increased proportion of R cells in the final composition of clones
with … We show that (1) NSCs show reduced proliferative activity with age, causing reduced …

Age-related memory decline, dysfunction of the hippocampus and therapeutic opportunities

L Dahan, C Rampon, C Florian - Progress in Neuro-Psychopharmacology …, 2020 - Elsevier
structure by histone post-translational modifications (more particularly, histone acetylation)
and DNA methylation. In the nucleus of the cell, … of resveratrol stimulate cell proliferation, high …

Sex differences and similarities in hippocampal cellular proliferation and the number of immature neurons during adolescence in rats

A Siddiqui, RD Romeo - Developmental neuroscience, 2019 - karger.com
… born cells in the dentate gyrus of the hippocampal formation. … decline in cellular proliferation
in this structure that occurs at … cellular proliferation and neurogenesis in the hippocampal

Experience-dependent structural plasticity of adult-born neurons in the aging hippocampus

MF Trinchero, M Herrero, MC Monzón-Salinas… - Frontiers in …, 2019 - frontiersin.org
… The granule cell (GC) layer is the information gateway to the HC and exhibits an age-dependent
decrease in activity that might impact directly on memory encoding. Input signals …

[HTML][HTML] Accelerated age-related decline in hippocampal neurogenesis in mice with noise-induced hearing loss is associated with hippocampal microglial …

H Zhuang, J Yang, Z Huang, H Liu, X Li… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… their cytoplasmic structure, such as deramified/atrophic cells (solid … with the previously
reported age-dependent decline in … First, the effect of aging on the proliferation in hippocampus is …

Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche

MP Fatt, LM Tran, G Vetere, MA Storer, JV Simonetta… - Stem Cell Reports, 2022 - cell.com
… We confirmed that, as predicted, these cells were non-proliferative by injecting 12 month
old mice with ethynyldeoxyuridine (EdU) and analyzing SA-β-Gal and EdU 24 h later. No SA-β-…

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

J Mertens, JR Herdy, L Traxler, ST Schafer… - Cell stem cell, 2021 - cell.com
age-dependent epigenetic erosion. To probe for the involvement of aging, we generated
rejuvenated iPSC-derived neurons … neuronal changes as age-dependent cellular programs that …

Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus

E Frías-Anaya, R Gromnicova, I Kraev… - Neurobiology of …, 2021 - Elsevier
potential effects of hormonal fluctuations on BBB structure that … age-dependent alterations,
the present study showed regional differences between the prefrontal cortex and hippocampus

Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone

G Lupo, R Gioia, PS Nisi, S Biagioni… - Journal of …, 2019 - journals.sagepub.com
… tissue organization, niche composition, and the regulatory … alteration in the proliferative
capacity of activated B1 cells … Encinas and colleagues 30 in the hippocampus. Using two different …

Longterm increased S100B enhances hippocampal progenitor cell proliferation in a transgenic mouse model

L Rodrigues, KM Wartchow, M Buchfelder… - International Journal of …, 2022 - mdpi.com
… In the postnatal development of rodents, an age-dependent increase in mRNA and protein
is evident [27,28]. In transgenic animals, GFAP participates in postnatal neurogenesis. In the …