… hypercholesterolemia (FH) is a genetic disorder caused by dysfunction of low density lipoprotein
receptors (LDLr), … evaluated age-related alterations in cognitive performance in LDLr -/- …

… the cognitive impairment trigger by hypercholesterolemia. … red wine consumption on
age-related diseases [Citation38,… with a lower risk of cognitive impairment in a cross-sectional …

… as hypercholesterolemia, which are caused due to LDLr defects, … LDL particles by directly
regulating insulin-mediated LDLr … of LDLr and IR by reducing the expression of LDLr and IR-…

… Here, we reviewed the main findings in LDLr -/- mice … , for instance, age-related cognitive
impairments. An interesting study … of LDL receptors and high cholesterol levels in LDLr-/- mice …

… in low-density lipoprotein receptor knockout mice (LDLr–/–), a … of LDLr–/–mice was observed
after a hypercholesterolemic … and cognitive impairment that we observed in LDLr –/– mice …

… in cognitive dysfunction associated with FH. We also investigated whether exposure to LDL
and LDLr … or systemic factors in the cognitive deterioration or negative regulation of adult …

… Age-related decrease in BBB permeability can be explained by … In the study, we used the
low-density lipoprotein receptor … -old mice allows us to hypothesize that cognitive impairment …

… via hepatocytes LDL receptors (LDLRs) and LDL receptor-… the animal studies of hyperlipidemia
and hypercholesterolemia [3]. … In transgenic animals, brain LDLR deficiency can induce …

… HDL can modulate cognitive function in aging and age-related … low-density lipoprotein
receptor (LDLR). PCSK9 binds the … for LDLR receptor causing familiar hypercholesterolemia (FH) …

… population are experiencing age-related memory impairment [2]. … 1 motif present on low
density lipoprotein receptors. The SREBF2 … as LDLR activators are required for enhancing LDLR …