… It is well-known that protein aggregation is a pathological hallmark shared among diverse …
5,6,7,8 . However, why amyloid-like aggregation of polyQ proteins is toxic to cells, especially to …

… proteins—which causes protein misfolding and aggregation, … its toxicity, particularly with
proteins involved in intracellular … factor, Sp1, and sequesters it away from its normal function in …

… The sequestration of vital proteins into aggregates formed by polyQ proteins is believed to
… In this study, we show that FUS is sequestered into ATXN7 aggregates to a high degree, …

… yet to be established, especially for aging-associated disorders. … aggregated species for
disease, protein aggregation is a … A small-molecule inhibitor (IU1) of ubiquitin-specific protease …

… phenotypes associated with polyglutamine expanded ATXN7 that … that is affected by regulated
sequestration and release of the DUBm… SUMOylation at lysine 257 reduces aggregation of …

… proteins and sequester them into amyloid-like aggregates. However, how these proteins
mutually coaggregate and sequester each other and how polyQ aggregates induce neuronal …

… species and that their formation may be important for cell survival due to their sequestration
… AR aggregation. USP7 is a ubiquitously expressed protein that possesses ubiquitin-specific …

… proteins involved in RNA metabolism (Table 1). Moreover, misfolded … proteins progressively
accumulate in neuronal nuclei where they form aggregates that sequester nuclear proteins …

… PRR of Atx7 25 , and aggregation of polyQ-expanded Atx7 specifically sequesters
ubiquitin-specific protease 22 (USP22) and … Aggregation of Polyglutamine-expanded Ataxin 7 …

… evoked by expression of polyglutamine-expanded ataxin-3 in … While the ubiquitin-specific
metalloproteases are comprised by … sequestered in aggregates of polyglutamine-expanded …