… -angiogenic signaling pathways, and finally inhibit angiogenesis in vitro. This study provides
further data support for the clinical application of Paris saponins as antiangiogenic drugs. …

… FGF and VEGF have been shown to be particularly important in the early stages of
angiogenesis, and we are interested in signaling crosstalk between these factors required to initiate …

… KLK10 acts by blocking the PI3K/AKT/mTOR signaling pathway… AKT/mTOR/NF-κB signaling
cascades, leading to apoptosis and cell proliferation inhibition, and altered the angiogenesis …

… CD137 signaling attenuated VEGFA secretion. In conclusion, activation of CD137
signaling promoted sprouting angiogenesis by increased VEGFA secretion and the VEGFR2/Akt/…

… angiogenesis, such as VEGF and bFGF (Gerber et al., 1998). Constitutive active PI3K …
Akt induce angiogenesis, and inhibition of PI3K signaling interferes with angiogenesis. PI3K …

… , AKT promotes angiogenesis by direct targeting and upregulating of key angiogenesis factors…
involved in degradation of extracellular matrix and angiogenesis promotion (35). The PI3K/…

… motility is the PI3K/AKT/mTOR signaling cascade. In the past … However, the central role of
PI3K/AKT/mTOR signaling varies … the role of the PI3K signaling pathway and the most recently …

… extracellular cues activate PI3K/AKT/mTOR. Dysregulation of … , insulin resistance and
angiogenesis. mTOR inhibitors are … Drugs targeting the PI3K/AKT/mTOR signalling pathway may …

… /Akt/endothelial NOS signaling that consequently promoted protective signaling and
angiogenesis. In … Disruption of CM p110β signaling compromised nuclear p110β and phospho-Akt …

… modulates the function of many downstream proteins involved in cellular survival, proliferation,
migration, metabolism, and angiogenesis. The Akt is a central node of many signaling …