[HTML][HTML] Research advances in the application of adipose-derived stem cells derived exosomes in cutaneous wound healing

Z Weiliang, G Lili - Annals of Dermatology, 2021 - ncbi.nlm.nih.gov
essential role of ADSCs in angiogenesis which is necessary … factors mediating wound
healing, like vascular endothelial … migration and proliferation by activating the AKT/HIF-1α axis. …

… -PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway

W Jiang, J Zhang, X Zhang, C Fan, J Huang - Bioengineered, 2021 - Taylor & Francis
… on wound healing, pathological changes, and angiogenesis … witnessed the development
of chronic skin ulcers including … encoding angiogenic cytokines such as vascular endothelial …

[HTML][HTML] Extracellular vesicles in skin wound healing

D Narauskaitė, G Vydmantaitė, J Rusteikaitė… - Pharmaceuticals, 2021 - mdpi.com
… of pro-angiogenic factor expression in vascular ECs; some of … in diabetic skin fibroblasts
through PI3K/Akt/mTOR signaling … promotes angiogenic effects by activating PI3K/Akt and ERK …

Autophagy and skin wound healing

H Ren, F Zhao, Q Zhang, X Huang, Z Wang - Burns & trauma, 2022 - academic.oup.com
… of vascular endothelial cells promotes wound angiogenesis … events and the PI3K/AKT/mTORC1
pathway inhibiting autophagy. … inhibitors and activators in development or clinical trials …

A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization …

H Li, M Li, P Liu, K Wang, H Fang, J Yin, D Zhu… - Biomaterials …, 2021 - pubs.rsc.org
… and expression of angiogenesis-associated factors via the PI3K/AKT signalling pathway in
… /AKT pathway is essential for normal and new blood vessel formation and development via …

[HTML][HTML] Role of periostin in skin wound healing and pathologic scar formation

SL Yin, ZL Qin, X Yang - Chinese Medical Journal, 2020 - mednexus.org
… invasion, and Akt phosphorylation level of KFs; when supplement … pathologic scar development
by promoting angiogenesis. … of important angiogenic cytokines in KFs, including vascular

Therapeutic role of extracellular vesicles derived from stem cells in cutaneous wound models: a systematic review

R Dalirfardouei, A Gholoobi, M Vahabian, E Mahdipour… - Life sciences, 2021 - Elsevier
angiogenesis was reported in twelve eligible studies through multiple signaling pathways
such as PI3K/Akt, MAPK/… MSC-EVs on skin wound healing which were outlined in the last part. …

The unconventional role of Akt1 in the advanced cancers and in diabetes-promoted carcinogenesis

A Alwhaibi, A Verma, MS Adil, PR Somanath - Pharmacological research, 2019 - Elsevier
… role of Akt1 in mediating tumor cell-vasculature reciprocity during the … cutaneous wound
healing model also revealed impaired angiogenesis and extracellular matrix remodeling in Akt1

[HTML][HTML] Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: new insight

G Mahmoudvand, A Karimi Rouzbahani… - Frontiers in …, 2023 - frontiersin.org
… These exosomes promote cutaneous wound healing via boosting angiogenesis and EPC …
In order to promote angiogenesis, these growth factors may stimulate Akt activation in vascular

SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress

X Li, G Wu, F Han, K Wang, X Bai, Y Jia, Z Li… - Archives of biochemistry …, 2019 - Elsevier
wound healing in diabetic mice by promoting angiogenesis. These positive therapeutic effects
may be mediated by protecting vascular endothelial cells from oxidative stress injury. … AKT