Induction of genomic instability in a primary human fibroblast cell line following low-dose alpha-particle exposure and the potential role of exosomes

EM Elbakrawy, A Mayah, MA Hill, M Kadhim - Biology, 2020 - mdpi.com
… primary non-transformed human lung fibroblasts. These cells … plateaus up to 0.5 Gy, with
evidence for a further increase at 1 … that the induction of sister chromatid exchanges in CHO and …

[PDF][PDF] An Analysis of Alpha Particle Radiation Exposure from the Population Level to the Biological Consequences

DD Pearson - 2021 - prism.ucalgary.ca
… Using biology and biochemistry, I present evidence that supports the hypothesis that SNM1C
functions to resolve DNA interstrand crosslink clustered together with DNA double strand …

Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration …

K Karthik, V Rajan, BN Pandey… - … Journal of Radiation …, 2019 - Taylor & Francis
… is challenged by the accumulating evidence of experimental non-… It was speculated to be
infinity using sister chromatid exchanges … working on alpha particle induced bystander effects. …

Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer

R Stainforth, J Schuemann, AL McNamara… - … journal of radiation …, 2021 - Taylor & Francis
… Empirical evidence across KERs can support construction of quantified AOPs (qAOPs).
Using an example AOP of energy deposition from ionizing radiation onto DNA leading to lung

Radiation-quality-dependent bystander cellular effects induced by heavy-ion microbeams through different pathways

M Suzuki, T Funayama, M Suzuki… - Journal of Radiation …, 2023 - academic.oup.com
… demonstrated increases in sister chromatid exchanges (SCEs) … apoptotic cell death of normal
human fibroblasts exposed to low … Normal human skin fibroblasts used in this study were …

Lethal and mutagenic bystander effects in human fibroblast cell cultures subjected to low-energy-carbon ions

M Suzuki, N Yasuda, H Kitamura - International Journal of …, 2020 - Taylor & Francis
… Conclusion: There is evidence that the bystander effects for … -particle irradiation induced
sister chromatid exchanges in >30… ) and normal human embryonic lung fibroblasts (Cell name, …

Environmental/Occupational exposure to radon and non-pulmonary neoplasm risk: a review of epidemiologic evidence

P Mozzoni, S Pinelli, M Corradi, S Ranzieri… - International Journal of …, 2021 - mdpi.com
… A variety of genetic lesions, including chromosomal damage, gene mutations, induction
of micronuclei, and sister chromatid exchange (SCE), have been associated with the DNA …

Radiation-induced bystander effect and its clinical implications

H Tang, L Cai, X He, Z Niu, H Huang, W Hu… - Frontiers in …, 2023 - frontiersin.org
… frequency of sister chromatid exchange. Contrarily, under … -blocked and normal groups,
finally obtaining direct evidence for the … So the team hypothesized that the alpha particle-induced

Targeting specific sites in biological systems with synchrotron x-ray microbeams for radiobiological studies at the photon factory

A Yokoya, N Usami - Quantum Beam Science, 2020 - mdpi.com
… Experimental evidence has shown that cell-to-cell … then measured the induction of sister
chromatid exchanges (SCE). … induced when five nuclei in normal human fibroblast cells (WI-38) …

Primary and secondary bystander effect and genomic instability in cells exposed to high and low linear energy transfer radiations

K Kanagaraj, V Rajan, BN Pandey… - … journal of radiation …, 2019 - Taylor & Francis
… Conclusion: This work adds evidence to secondary … Citation2013) and normal human
fibroblast followed by γ- … , Mumbai, currently working on alpha particle induced bystander effects. …