… patients with myeloid leukemia and is closely related … gene expression profile of T cells from
chronic myelogenous leukemia … patients by microarray analysis and investigated the related …

… chronic myeloid leukemia and acute myeloid leukemia evade the immune response during
their development and disease progression. As myeloid leukemia … of TCRζ (T cell receptor ζ) …

… Especially patients relapsed after at least three to four therapy lines, non-transplant eligible
as well as high risk patients might benefit from CAR therapy as an alternative to already …

… can lead to severe graft-versus-host disease (GvHD). An alternative approach would bolster
… a phase-I study for the treatment of patients with acute myeloid leukemia (AML) [146]. A 3rd …

… leukaemia (ALL), acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL) and
chronic myeloid leukaemia (CML). This … TCRζ-chain expression is essential for proper T cell …

… In contrast, 4-1BBζ CAR T cells preferentially expressed T cell memory-associated genes
and exhibited sustained anti-tumor activity against established experimental tumors [Citation…

… : Both chronic myeloid leukemia and acute myeloid leukemia … of TCRζ (T cell receptor ζ)
and limited cytotoxic function and … Alternative Expression of TCRζ Related Genes in Patients …

… and CD137 in series with signals from the TCRζ chain. The Journal of … follows progressive
epigenetic changes that impart unique gene expression profiles and functions.It has been …

… be causal variants associated with low expression of TCRζ in … SRSF1 regulates the
alternative splicing of the 3'UTR of … tumours (lymphoma 3 and chronic myeloid leukaemia 86 ), …

… was also associated with severe toxicity in one animal model. Prior to clinical translation,
alternate … We found that CARs with 2B4 or 4-1BB costimulatory and TCRζ signaling domains …