… Advances in digital pathology and technologies such as single cell sequencing and digital
spatial profiling have opened novel avenues for improvement of neuropathological diagnosis …

… biomarkers) compare. We therefore tested a variety of AT(N) approaches, with different …
We hypothesized that different AT(N) variants would have considerable differences in …

… Alzheimer disease (AD) is a form of neurocognitive disorder, clinically characterized by a
multidomain cognitive impairment with progressive decrease in the abilities to perform daily …

… Indeed, in one study of 184 individuals who met research neuropathological criteria for
AD 9 , 31% had only AD pathology, 22% had AD pathology plus α-synuclein pathology (Lewy …

… Since CTE is characterized by the distinct distribution of hyperphosphorylated tau pathology
seen in AD, we discuss the differences in tau levels in biofluids in these diseases, including …

… Gamma-Secretase modulators to prevent neurodegeneration in mouse models of Down
Syndrome and Alzheimer disease We aim to prevent Alzheimer disease (AD) in adults with DS (…

… Alzheimer's Association (AA) began its existence in 1980 as the Alzheimer's Disease and
Related Disorders … a similar approach; for example, the Alzheimer's Foundation or Us Against …

… human APOE into these mouse models (“Who”). We next outline different methods for
introducing human … defined and location-specific human apoE expression models (“When” and “…

… compare AD-like pathology in aging vervets using protocols aligned with human
neuropathological … those used in assessment of human AD neuropathologic change. We …

… To our knowledge, this is the first time Alzheimer disease neuropathology has been … a
generalized linear model, modeling the logit of the binomial AD neuropathology outcome, with …