Clinical and Mechanistic Review of Amiodarone-Associated Optic Neuropathy

R Mitchell, J Chacko - Biomolecules, 2022 - mdpi.com
IGF-1 promoted RPE cell survival from amiodarone-induced … of AM on apoptosis is attenuated
by addition of IGF-1 over a … proapoptotic mechanisms of cell death from amiodarone [37]. …

[HTML][HTML] Insulin-like growth factor-1 stimulates retinal cell proliferation via activation of multiple signaling pathways

CS de Figueiredo, Í Raony, SV Medina… - Current Research in …, 2023 - Elsevier
… (CNS), including the retina, regulating cell proliferation, … In addition, our results indicates
that IGF-1-induced retinal cell … from rat neural retina, we showed for the first time that IGF-1

New insights into amiodarone induced retinal and optic nerve toxicity: functional and structural changes

WM Ebeid, AAEF El-Shazly, NM Kamal… - … Advances in …, 2023 - journals.sagepub.com
… and function of the retina and optic nerve with controversial … structure and function of the
retinal and optic nerve in patients on … via macular and optic nerve head (ONH) OCT and OCTA. …

Amiodarone Advances the Apoptosis of Cardiomyocytes by Repressing Sigmar1 Expression and Blocking KCNH2-related Potassium Channels

H Liang, H Li, F Li, X Xiong… - Current Molecular …, 2024 - ingentaconnect.com
… of ROS in retinal pigment epithelial cells, triggering lipid … Evaluation and treatment of
amiodarone-induced thyroid … , attenuates hypoxia-induced cell death via mitochondrial KATP …

[HTML][HTML] Acteoside protects retinal ganglion cells from experimental glaucoma by activating the PI3K/AKT signaling pathway via caveolin 1 upregulation

X Xi, Q Chen, J Ma, X Wang, Y Xia, X Wen… - Annals of …, 2022 - ncbi.nlm.nih.gov
… staining were used to detect cell apoptosis. The reactive oxygen … In addition, Cav1 can
regulate cell apoptosis, inflammation, … attenuates oxidative stress-induced neuronal apoptosis in …

Amiodarone promotes heat-induced apoptosis, inflammation and oxidative stress in mouse HL1 atrial myocytes

H Zhao, Z Tan, L He, S Zhu, R Yan, H Kou… - … xue bao= Journal of …, 2021 - europepmc.org
… Heat exposure of HL1 atrial myocytes was conducted using a water bath, and the effect
of amiodarone on cell viability was assessed with MTS method; cell apoptosis was detected …

Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats

B Wang, X Lin, J Zhou, C Xie, C Li… - Experimental and …, 2021 - spandidos-publications.com
… of IGF-1 significantly reduced neuronal apoptosis in the … indicated IGF-1 had a protective
role in POCD by attenuating … activation of the apoptotic protease by regulating its structure and …

IGF1 inhibits palmitic acid‑induced mitochondrial apoptosis in macrophages

W Tang, M Zhang, Y Wang, D Ma… - Molecular …, 2023 - spandidos-publications.com
… for the analysis of cell apoptosis (early + late apoptotic cells) in … suggested that IGF-1
attenuated macrophages apoptosis. … that IGF-1 can reduce lipopolysaccharide-induced neuronal

ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway

C Cui, S Han, X Shen, H He, Y Chen, J Zhao… - Cell and tissue …, 2020 - Springer
cell apoptosis via IGF/PI3K/AKT-FOXO signaling pathway. … that it participates in atrophy
through the IGF-1/PI3K/AKt pathway. … attenuates the igf-1-induced apoptosis of retinal neurons

Insulin-like growth factor-1 enhances motoneuron survival and inhibits neuroinflammation after spinal cord transection in zebrafish

L Zhao, B Zhang, S Huang, Z Zhou, X Jia… - Cellular and Molecular …, 2022 - Springer
… ganglion cells) from amiodarone-induced apoptosis by stimulating the PI3K/Akt/FoxO3a …
neuronal protective effect of IGF-1 in zebrafish. Similarly, cell death reduction of motor neurons