Endothelial mitochondrial dysfunction in cerebral amyloid angiopathy and Alzheimer's disease

R Parodi-Rullán, JY Sone… - … of Alzheimer's disease, 2019 - content.iospress.com
… to cerebral endothelial cell (CEC) dysfunction and death [18]. Microvascular degeneration
… be involved in Aβ-induced brain endothelial dysfunction. Rat brain endothelial cells treated …

Amyloid-β causes mitochondrial dysfunction via a Ca 2+-driven upregulation of oxidative phosphorylation and superoxide production in cerebrovascular endothelial …

DD Quintana, JA Garcia, Y Anantula… - … Disease, 2020 - content.iospress.com
… For all procedures performed in this study that involved the use of laboratory animals were
carried out in accordance with the National Institutes of Health guide for the care and use of …

Beta-amyloid instigates dysfunction of mitochondria in cardiac cells

S Jang, XR Chapa-Dubocq, RM Parodi-Rullán… - Cells, 2022 - mdpi.com
… Alzheimer’s disease (AD) includes the formation of … , similar mitochondrial dysfunction and
apoptotic mechanisms were shown by our group in cerebral microvascular endothelial cells

… the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer's disease

RM Parodi-Rullán, S Javadov, S Fossati - Cells, 2021 - mdpi.com
… parenchymal senile plaques composed of amyloid β (Aβ) and … of the mitochondria, specifically
of cerebral endothelial cells, … the role of Aβ-induced mitochondrial dysfunction in ECs, how …

Distinct effects of beta-amyloid, its isomerized and phosphorylated forms on the redox status and mitochondrial functioning of the blood–brain barrier endothelium

AV Petrovskaya, AM Tverskoi, EP Barykin… - International Journal of …, 2022 - mdpi.com
… a greater cytotoxicity and mitochondrial dysfunction, causing … of an Aβ-induced BBB
breakdown involves alterations in … form on the mouse brain endothelial cells bEnd.3 to assess …

GSH-AuNP anti-oxidative stress, ER stress and mitochondrial dysfunction in amyloid-beta peptide-treated human neural stem cells

MC Chiang, CJB Nicol - Free Radical Biology and Medicine, 2022 - Elsevier
Mitochondria are cellular organelles with biogenesis, a buffer of intracellular calcium … the
ER and mitochondria, and they are involved in neuronal synaptic functions and apoptosis [32]. …

[HTML][HTML] Brain endothelium-derived extracellular vesicles containing amyloid-beta induce mitochondrial alterations in neural progenitor cells

OM Osborne, JM Kowalczyk, KDP Louis… - Extracellular vesicles …, 2022 - ncbi.nlm.nih.gov
… NPC differentiation and induce mitochondrial dysfunction, leading … are incorporated into
cerebral structures involved in learning … showed that exposure of brain endothelial cells to Aβ 40 …

Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction

G Zhou, Q Ye, Y Xu, B He, L Wu, G Zhu, J Xie… - International …, 2023 - Elsevier
… Human umbilical vein endothelial cells (HUVECs) and HEK293T cells were obtained from
… , we then explored whether pyroptotic cell death might be involved for MICU3 against CAA …

Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction

B Pang, G Dong, T Pang, X Sun, X Liu, Y Nie, X Chang - Angiogenesis, 2024 - Springer
… of mitochondrial-induced vascular endothelial cell injury in … -related diseases, cerebrovascular
diseases, and microvascular … Mitochondrial dynamics involve mitochondrial fission and …

The protective effect of ubiquinone against the amyloid peptide in endothelial cells is isoprenoid chain length-dependent

J Frontiñán-Rubio, Y Rabanal-Ruiz, M Durán-Prado… - Antioxidants, 2021 - mdpi.com
… 35 -induced mitochondrial dysfunction. It … -induced deleterious effects in endothelial cells
also involves these mechanisms, reducing Aβ trafficking and accumulation into the mitochondria