Pathogenesis of perianal fistulising Crohn's disease: current knowledge, gaps in understanding, and future research directions

S Cao, M Colonna, P Deepak - Journal of Crohn's and Colitis, 2023 - academic.oup.com
… metalloproteinases [MMPs], which can degrade extracellular matrix … CD perianal fistulas
Faecal samples and perianal fistula biopsies … may identify new cellular pathways involved in the …

Cellular therapy treatment of chronic radiation cystitis in rats

C Brossard, M Dos Santos, M Benadjaoud… - … Federation for Adipose …, 2019 - hal.science
… in the most severe cases to fistulas with symptoms such as pain and bleeding. There is no …
treatment and we propose to test mesenchymal stem cells (MSC) as a new therapeutic method

Current Status and Clinical Applications of Tissue Engineering of the Gastrointestinal Tract: A Systematised Narrative Review

Y Liu, L Chong, M Read - Frontiers in Gastroenterology, 2023 - frontiersin.org
… for treating full-thickness defects (eg, perianal fistulas), as … of studies have used extracellular
matrices (ECMs) with … after removal of the cellular and immunogenic components (2, …

The pathogenesis and clinical management of stricturing Crohn disease

CJ Schmoyer, J Saidman, JL Bohl… - Inflammatory Bowel …, 2021 - academic.oup.com
… of extracellular matrix proteins. Our understanding of this process has grown and encompasses
cellular … This technique has been used in CD to identify aberrant immune signatures …

[PDF][PDF] Cell-assisted lipotransfer in treating uncontrollable sepsis associated perianal fistula: a pilot study

IS Jeong, SH Hwang, HM Yu… - Journal of the Korean …, 2023 - coloproctol.org
… A new method of treating refractory complex perianal fistulas is to use stem cells, such as …
In examining the therapeutic efficacy of SVF, we expect multipotent cellular components to …

Extracellular matrix dynamics in inflammatory bowel diseases

E Shimshoni - 2020 - search.proquest.com
… my research and opening the door for me to a variety of new disciplines and techniques. …
The extracellular matrix (ECM) comprises a large portion of any mammalian tissue. Cells …

[PDF][PDF] The dead space after extirpation of rectum. Current management and searching for new materials for filling

M Bocková, J Hoch, A Kestlerová, E Amler - Physiological Research, 2019 - biomed.cas.cz
… The techniques used are primary suture, plastic surgery using … are made of human acellular
dermal matrix. It is declared … structure of the extracellular matrix, which provides a suitable …

Human adipose-derived stem cells with great therapeutic potential

M Sheykhhasan, JKL Wong… - … cell research & therapy, 2019 - ingentaconnect.com
… cells for tissue and extracellular matrix formation, and … considered a safe treatment for
Perianal Fistulas disease that … the differentiation of ADSCs and due to cellular fusion [126]. …

Porcine dermal collagen mesh (Permacol™) as a bioprosthesis in the ligation of intersphincteric tract (BioLIFT) procedure

JS Tsang, TY Chan, HH Cheung, R Wei… - Techniques in …, 2020 - Springer
… of a non-cross-linked acellular collagen matrix. Further developments of … extracellular matrix.
Supplementary cross-linking using hexamethylene diisocyanate provides a collagen matrix

Improved fistula plug outcome depends on the type of plug: a single‐centre retrospective study

AE Sayers, MJ Lee, SR Brown - Colorectal Disease, 2023 - Wiley Online Library
… (1–7) Transsphincteric fistulas are the second most … extracellular matrix material which is
deri ved from porcine small intestinal submucosa.(22) Fistula plug B is made from an acellular