Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

DH Nguyen, B Soygur, SP Peng, S Malki, G Hu… - Nature cell …, 2020 - nature.com
… our hypothesis that earlier errors in germ-cell epigenetic … that apoptosis during male germline
development functions as a … , diffusible apoptotic signals are therefore not necessary for …

Human germ cell tumours from a developmental perspective

JW Oosterhuis, LHJ Looijenga - Nature Reviews Cancer, 2019 - nature.com
… PGCs, before the first wave of demethylation, also called … factor, may have the same
function in the regulation of gene … earlier, the important role of PGCs escaping apoptosis in the …

Testicular germ cell apoptosis and spermatogenesis

B Singh, G Gupta - … Signaling in Spermatogenesis and Male …, 2019 - taylorfrancis.com
… , and its function is to maintain a pool of stem cells and to produce … Apoptosis of the germ
cell is necessary for the maintenance … An initial inhibition of germ cell apoptosis after MEHP …

Germ cell reprogramming

K Kurimoto, M Saitou - Current Topics in Developmental Biology, 2019 - Elsevier
… of physiologically functional mouse primordial germ cells (… of the early mesoderm program,
and is reacquired during the … are eliminated by extensive germ cell death, and a limited …

Actions and roles of FSH in germinative cells

K Recchia, AS Jorge, LVF Pessôa, RC Botigelli… - International Journal of …, 2021 - mdpi.com
… in the induction of germ cells and germ-cell-like cells in vitro. … germ cells, it regulates and
limits the wave of apoptosis of … for functional germ cells. They are fundamental to protecting …

Retinoic acid and germ cell development in the ovary and testis

T Endo, MM Mikedis, PK Nicholls, DC Page… - Biomolecules, 2019 - mdpi.com
… Instead, Stra8 is first expressed much later in germ cells of … to prevent their aberrant
differentiation state and apoptosis. … By identifying RA functions in post-meiotic cells, future studies …

During infancy low levels of follicle-stimulating hormone may result in high rate of germ cell apoptosis

S Hildorf, D Cortes, J Thorup, E Clasen-Linde… - Journal of Pediatric …, 2021 - Elsevier
… act as a factor essential for promoting germ cell survival in the … wave of spermatogenesis,
which is after minipuberty and at … the role of FSH in germ cell apoptosis during early infancy in …

Heterogeneity of primordial germ cells

DH Nguyen, RG Jaszczak, DJ Laird - Current topics in developmental …, 2019 - Elsevier
… the potential for PGC development to function as a multistage … perspective on early events
in germ cell development with a … Apoptosis was preceded by downregulation of key germ cell

Global changes in epigenomes during mouse spermatogenesis: possible relation to germ cell apoptosis

T Koji, Y Shibata - Histochemistry and Cell Biology, 2020 - Springer
… of such trigger may require a thorough understanding of the … cell death in the first and third
peaks is regarded as apoptosis… On the other hand, DNMT3a and DNMT3b function primarily …

A matter of new life and cell death: programmed cell death in the mammalian ovary

MS Chesnokov, AR Mamedova, B Zhivotovsky… - Journal of Biomedical …, 2024 - Springer
… —progenitor germ cell … an essential element in ovarian development, functions and
pathologies. A thorough understanding of molecular mechanisms regulating PCD events is required