SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis
T Lehtiniemi, M Bourgery, L Ma… - Nucleic acids …, 2022 - academic.oup.com
… that in germ cells, the CB participates in the function of NMD … To achieve this, we first created
a mouse line harboring loxP … In addition to a dramatic increase in apoptotic germ cells in …
a mouse line harboring loxP … In addition to a dramatic increase in apoptotic germ cells in …
[HTML][HTML] Sertoli cells as key drivers of testis function
L O'Donnell, LB Smith, D Rebourcet - Seminars in Cell & Developmental …, 2022 - Elsevier
… the development of up to five different types of germ cells at … types of spermatogonia, one to
two types of spermatocytes and … levels of germ cell apoptosis that can vary between cell types …
two types of spermatocytes and … levels of germ cell apoptosis that can vary between cell types …
[HTML][HTML] Loss of ubiquitin carboxy-terminal hydrolase L1 impairs long-term differentiation competence and metabolic regulation in murine spermatogonial stem cells
WF Alpaugh, AL Voigt, R Dardari, L Su, I Al Khatib… - Cells, 2021 - mdpi.com
… tubules were spermatogonia and Sertoli cells, we … early and massive wave of germ cell
apoptosis during the pre-pubertal stage of development, a phase that is essential for functional …
apoptosis during the pre-pubertal stage of development, a phase that is essential for functional …
[HTML][HTML] E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish
H Xie, Y Kang, S Wang, P Zheng, Z Chen, S Roy… - PLoS …, 2020 - journals.plos.org
… Germ cell apoptosis is a common consequence of meiotic … It has been shown earlier that
mutation of the apoptotic gene … its function as a transcription repressor during cell division, E2f5 …
mutation of the apoptotic gene … its function as a transcription repressor during cell division, E2f5 …
Somatic-immune cells crosstalk in-the-making of testicular immune privilege
… growth arrest specific gene 6 (Gas6) which is their functional … germ cell apoptosis during the
onset of spermatogenesis in … aid their apoptosis at the time of first spermatogenic wave [42, …
onset of spermatogenesis in … aid their apoptosis at the time of first spermatogenic wave [42, …
YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells
X Zhao, Z Lin, Y Fan, W Li, Y Zhang, F Li… - Acta Biochimica et …, 2021 - academic.oup.com
… has fundamental function during mouse spermatogenesis. … in epididymides, so we
hypothesized that apoptosis occurred … two types of germ cells, ie diplotene spermatocytes and …
hypothesized that apoptosis occurred … two types of germ cells, ie diplotene spermatocytes and …
[HTML][HTML] Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility
M Joshi, S Rajender - Reproductive Biology and Endocrinology, 2020 - Springer
… germ cells to identify lncRNAs regulating spermatogenesis. In … play a functional role in
spermatogenesis and male fertility. … pachytene spermatocytes undergoing apoptosis were seen in …
spermatogenesis and male fertility. … pachytene spermatocytes undergoing apoptosis were seen in …
[HTML][HTML] A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis
… Spermatogonia are the mitotic germ cells encompassing the … IX-X) accompanied by apoptosis
(Fig. 3f, g and Figs. S3–4). … an essential embryonic function for TUT4/7 in regulating growth …
(Fig. 3f, g and Figs. S3–4). … an essential embryonic function for TUT4/7 in regulating growth …
Deletion of the mouse X‐linked Prame gene causes germ cell reduction in spermatogenesis
C Lu, M Yang, RM Rossi, A Wang… - … and development, 2020 - Wiley Online Library
… the functional role of PRAME in vivo during spermatogenesis, … Prame is deleted in early germ
cells before entering meiosis. … + pachytene spermatocytes because of cell apoptosis at P14…
cells before entering meiosis. … + pachytene spermatocytes because of cell apoptosis at P14…
Microenvironment for spermatogenesis and sperm maturation
H Miyaso, Y Ogawa, M Itoh - Histochemistry and cell biology, 2022 - Springer
… disorders are involved in functional failure of the male … apoptosis after birth is around
postnatal days 10–13, when the first wave of spermatogenesis begins in mice, although germ …
postnatal days 10–13, when the first wave of spermatogenesis begins in mice, although germ …