[HTML][HTML] An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
… iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in
C9ORF72… to derive a separate set of C9ORF72 and control motor neurons. Many individual -…
C9ORF72… to derive a separate set of C9ORF72 and control motor neurons. Many individual -…
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
…, Integrative Analysis and Computational Modeling… - bioRxiv, 2020 - biorxiv.org
… The goal of the current study was to use a multi-omic approach to test whether a network-based
analysis would facilitate identification of early pathogenic events in C9 ALS where the …
analysis would facilitate identification of early pathogenic events in C9 ALS where the …
An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
E Fraenkel - 2021 - dspace.mit.edu
… The goal of the current study was to use a multi-omic approach to investigate whether a
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …
[PDF][PDF] An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
L Svendsen, M Thompson - core.ac.uk
… The goal of the current study was to use a multi-omic approach to investigate whether a
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …
network-based analysis would facilitate identification of early pathogenic events in C9-ALS …
Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS
… Our results reveal aberrant lipid metabolism in 17 ALS patient-… hESC- and iPSC-derived
oMN-like molecular patterns … two types of motor neurons of SOD1 A4V and C9ORF72 lines, we …
oMN-like molecular patterns … two types of motor neurons of SOD1 A4V and C9ORF72 lines, we …
[PDF][PDF] INTEGRATIVE MULTI-OMICS PROFILING IN AMYOTROPHIC LATERAL SCLEROSIS: TOWARD PRECISION MEDICINE
G Maria, A Morello - iris.unict.it
… Integrated analysis of CNVs and gene expression profiling … in the motor cortex of
sporadic ALS patients, we performed a … of motor neurons in both the motor cortex, brainstem …
sporadic ALS patients, we performed a … of motor neurons in both the motor cortex, brainstem …
[HTML][HTML] Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
EG Baxi, T Thompson, J Li, JA Kaye, RG Lim… - Nature …, 2022 - nature.com
… (iPS) cell lines, multi-omic data derived from iPS neurons and … employing iPS spinal neurons
from patients with C9orf72 ALS/… Non-ALS motor neuron disease (MND) included patients …
from patients with C9orf72 ALS/… Non-ALS motor neuron disease (MND) included patients …
[HTML][HTML] Cross-comparison of human iPSC motor neuron models of familial and sporadic ALS reveals early and convergent transcriptomic disease signatures
… sequencing (scRNA-seq) analysis to address these limitations. … , isogenic patient lines were
established from two C9orf72 ALS … Modeling sporadic ALS in iPSC-derived motor neurons …
established from two C9orf72 ALS … Modeling sporadic ALS in iPSC-derived motor neurons …
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
E Fraenkel - 2022 - dspace.mit.edu
… (iPS) cell lines, multi-omic data derived from iPS neurons and … iPS spinal neurons from
patients with C9orf72 ALS/ … foci in iPSC-derived motor neurons from ALS patients with a …
patients with C9orf72 ALS/ … foci in iPSC-derived motor neurons from ALS patients with a …
[HTML][HTML] From multi-omics approaches to precision medicine in amyotrophic lateral sclerosis
… ALS is the most common adult motor neuron disease with a … , the use of iPSC derived from
patients suffering from ALS has … in ALS or ALS/FTD patients carrying C9ORF72 expansion …
patients suffering from ALS has … in ALS or ALS/FTD patients carrying C9ORF72 expansion …