Research progress of small molecule VEGFR/c-Met inhibitors as anticancer agents (2016–Present)

Q Zhang, P Zheng, W Zhu - Molecules, 2020 - mdpi.com
… In this review, we comprehensively summarize the chemical … novel VEGFR/c-Met dual-target
small-molecule inhibitors in … Therefore, inhibition of the VEGFR-2/VEGF signaling pathway …

Signaling pathway and small-molecule drug discovery of FGFR: A comprehensive review

J Zheng, W Zhang, L Li, Y He, Y Wei, Y Dang… - Frontiers in …, 2022 - frontiersin.org
… This review starts by introducing the biological basis of FGF/FGFR signaling. It then gives a
detailed … FGFR/EGFR dual inhibitors can be exemplified by FIIN3, while FGFR/VEGFR dual …

Therapeutic inhibition of VEGF signaling and associated nephrotoxicities

CC Estrada, A Maldonado… - Journal of the American …, 2019 - journals.lww.com
… We also review the renal effects of VEGF inhibition’s mediation of key downstream signaling
… Direct VEGFA inhibition via antibody binding or VEGF trap (a soluble decoy receptor) is …

Small molecule inhibitors targeting the cancers

GH Liu, T Chen, X Zhang, XL Ma, HS Shi - MedComm, 2022 - Wiley Online Library
… At the end of our review, we also discuss the main issues and future directions concerned
… with anti-FGFR activity often simultaneously target VEGF/VEGFR signaling, thereby …

An updated patent review of VEGFR-2 inhibitors (2017-present)

TA Farghaly, WA Al-Hasani… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Angiogenesis is a vital process for cellular … VEGF/VEGFR-2 signaling pathway
has been recognized as … In this review, we described small-molecule VEGFR-2 inhibitors

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update

R Roskoski Jr - Pharmacological research, 2020 - Elsevier
… endothelial growth factor receptors (VEGFR), epidermal growth … This review presents the
physicochemical properties of all of … Pexidartinib inhibition of CSF1 and CSF1R signaling thus …

Properties of FDA-approved small molecule protein kinase inhibitors

R Roskoski Jr - Pharmacological research, 2019 - Elsevier
… endothelial growth factor receptor (VEGFR). Most of the small molecule inhibitors (45)
interact … This review presents the available drug-enzyme X-ray crystal structures for 27 of the …

An update of new small-molecule anticancer drugs approved from 2015 to 2020

X Liang, P Wu, Q Yang, Y Xie, C He, L Yin, Z Yin… - European Journal of …, 2021 - Elsevier
… In this review, we provide a summary of all fifty-six of these … The former exerts a transduction
of extracellular signals into … as vascular endothelial growth factor (VEGF), fibroblast growth …

Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer

F Sarwar, S Ashhad, A Vimal, R Vishvakarma - Medical Oncology, 2024 - Springer
… This review paper highlights the genesis of cervical cancer and … small molecule inhibitors
inhibit intracellular signaling by attaching to catalytic sites where ATP binds in VEGFR's

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
… After imatinib, >20 other small molecule inhibitors were … current review article is focussing
on the structure of VEGFR-… by VEGFR-2 signaling pathway [54,55]. In the cancer cells, …