… of transdermal formulations of lappaconitine liposome gel. Methods Analgesic effect of
lappaconitine liposome gel and lappaconitine gel was investigated by mouse hot plate test and …

… previous studies have mainly investigated the analgesic effect of LA at the … analgesic effects
of two homologous derivatives of LA, Lappaconitine hydrobromide (LAH) and Lappaconitine …

… Moreover, multiple daily intraperitoneal injection of lappaconitine blocked spontaneous pain
in a mouse leukemia bone cancer pain model [8]. The analgesic activity of lappaconitine 1 …

… By using NGF antibody, lappaconitine, or toad skin extract to restore MOR expression, then,
bone pain caused by breast cancer or leukemia can be alleviated, indicating that MOR might …

… In this study an animal model of pharmacopuncture using ASN (100-500 mg/kg) was …
lappaconitine reportedly had an analgesic effect in a mouse model of leukemia-induced bone pain …

… In addition, many of the active ingredients, such as lappaconitine, ranaconitine and total …
which has remarkable analgesic effects, is traditionally used for the treatment of rheumatic pain, …

… highly expressed in the lesions in the RA animal model. TNF-α can improve the expression
… analgesic effect in the treatment of trigeminal neuralgia disease, and its analgesic effect is …

… distress their analgesic effects in clinical … animal models in the following study. Besides,
LH exerts an outstanding anticancer activity, and it is conceivable to further explore its effect in …

… bone pain [35]. Of note, several clinical trials demonstrated that bone pain and use of
analgesic … , recent preclinical studies showed that treating mouse models of CIBP with either an …

… -1R antagonists in chronic pain of leukemia patients. To assess the analgesic effect of NK-1R
antagonism, we exploited a bone pain mouse model involving intratibia injection of CML …