… receptors [75]. Such a resistance mechanism may occur for the androgen receptor signaling
… Most common androgen receptor (AR) mutations in prostate cancer and associations with …

… Thirdly, mutations in the androgen receptor ligand binding … roles in androgen receptor
signaling in prostate cancer cells. … The role of GATA2 in androgen signaling was first implicated …

… prostate cancer has led to development of therapeutic strategies targeting androgen receptor
(… these inhibitors is limited as NTRK mutations are rarely detected in prostate cancer [126]. …

… Androgen receptor (AR) signaling remains an important … PCa, making disruption of AR
signaling a viable therapy option. … SPOP mutant induced AR signaling and ERG fusion signaling […

… and mutations leading to increased androgen receptor protein expression and activating point
mutants (… Changes in RNA splicing generate constitutively active androgen receptor splice …

… therapies including androgen deprivation therapy and androgen receptor (… prostate cancer.
However, treatment resistance emerges after hormonal manipulation in most prostate cancers…

… CWR22 PDX is derived from a primary prostate cancer with an AR H875Y mutation from a
hormone treatment-naïve European-American patient [12]. Its xenograft growth in adult male …

… Castration resistant prostate cancer (CRPC) continues to be androgen receptor (AR) driven.
Inhibition of AR signaling in CRPC could be advanced using state-of-the-art biophysical and …

… androgen receptor (AR) in prostate cancer has been extensively studied. Recent data suggest
that AR signaling may also be important in breast cancer… Notably most identified mutations …

… of androgen signaling in prostate cancer biology and advances made over the years to
effectively target this signaling … Majority of the AR point mutations in prostate cancer have been …