Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy

WW Zhang, RH Zheng, F Bai, K Sturdivant… - Molecular Biology …, 2020 - Springer
… Given the fact that the recovery in cardiac function by an aldosterone receptor antagonist
is due to the blockade of fibrotic process in the heart [19, 20], we hypothesized that Ang …

An overview of the classical and tissue-derived renin-angiotensin-aldosterone system and its genetic polymorphisms in essential hypertension

MTA Ghafar - Steroids, 2020 - Elsevier
… by angiotensin II leads to rapid denovo aldosterone synthesis, … glucocorticoid regulated
kinase 1 (sgk1), glucocorticoid-… feature of angiotensin II paracrine control of renal function. …

Eplerenone improves pulmonary vascular remodeling and hypertension by inhibition of the mineralocorticoid receptor in endothelial cells

J Kowalski, L Deng, C Suennen, D Koca, D Meral… - …, 2021 - Am Heart Assoc
aldosterone, we measured gene expression in human pulmonary artery endothelial cells after
aldosterone … In addition, aldosterone induced PH without affecting LV function, suggesting …

[HTML][HTML] Mineralocorticoid receptor signalling in primary aldosteronism

J Yang, MJ Young, TJ Cole… - Journal of …, 2023 - joe.bioscientifica.com
… Dephosphorylation in response to angiotensin II provides a mechanism by which the
aldosterone-… Modulation of B cell function via the MR in patients with PA remains unexplored. …

Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms

J Bauersachs, A Lother - Kidney International Supplements, 2022 - Elsevier
… –angiotensinaldosterone system. The physiological role of … LV function, but in contrast to
ischemic injury, it did not regulateAngiotensin II-induced hypertension and subsequent organ …

Adrenal tissue-specific deletion of TASK channels causes aldosterone-driven angiotensin II–independent hypertension

NA Guagliardo, J Yao, EJ Stipes, S Cechova, TH Le… - …, 2019 - Am Heart Assoc
… in no obvious abnormalities in pulmonary or renal function. … )-TASK-KO mice is Ang II (angiotensin
II)–independent. Diurnal … Mineralocorticoid receptor antagonism with spironolactone (…

Effect of angiotensin II on ENaC in the distal convoluted tubule and in the cortical collecting duct of mineralocorticoid receptor deficient mice

P Wu, ZX Gao, DD Zhang, XP Duan… - Journal of the …, 2020 - Am Heart Assoc
… load under physiological conditions, gain‐of‐function‐mutations of ENaC are associated with
… Since aldosterone plays a key role in the regulation of ENaC, we then examined effects of …

Aldosterone and mineralocorticoid receptor antagonists on pulmonary hypertension and right ventricular failure: a review

N Omidkhoda, F Vakilian… - Current …, 2020 - ingentaconnect.com
… not raise aldosterone, suggesting that aldosterone synthesis … The functional outcomes of
aldosterone were regulated by … (ET), angiotensin II (Ang II) and aldosterone) in the proliferation …

[图书][B] Endothelial Mineralocorticoid Receptors in Cerebrovascular and Cognitive Function in Angiotensin II-Hypertension

JM Díaz-Otero - 2019 - search.proquest.com
… actions of aldosterone in all cell types in the arteries. … and these are regulated by
mineralocorticoid receptor activation ...… TRPV4 and IKCa/SKCa mRNA expression in AngII-hypertension …

Mineralocorticoid dysfunction during critical illness: a review of the evidence

GD Nethathe, J Cohen, J Lipman, R Anderson… - …, 2020 - pubs.asahq.org
… -talk exists between angiotensin II and aldosterone, which … angiotensin I and angiotensin II
receptors, mineralocorticoid … local or tissue axes that regulate renal function, blood pressure, …