Renin-angiotensin-aldosterone system in heart failure: focus on nonclassical angiotensin pathways as novel upstream targets regulating aldosterone

U Tyrankiewicz, A Kij, T Mohaissen… - … -Mineralocorticoid …, 2019 - books.google.com
… by angiotensin II, while angiotensin-(1–7) negatively regulates angiotensin II-mediated
aldosterone … MasR genetic deletion leads to impairment of cardiac function and endothelial …

Role of mineralocorticoid receptor antagonists in kidney diseases

V Patel, A Joharapurkar, M Jain - Drug development research, 2021 - Wiley Online Library
… the expression of several genes (Figure 1). The adrenal cortex releases aldosterone in
response to either renin-angiotensin … directly regulates the inflammatory cell function in kidneys. …

Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension

R Zhang, S Shi, DA Jadhav, N Kim, A Brostek… - bioRxiv, 2024 - biorxiv.org
… the ED() function was used to determine the 169 aldosteronegene expression: Genomewide
differential gene expression … : overexpression of type 1 angiotensin II 606 receptor in …

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells

R Fu, K Wellman, A Baldwin, J Rege, K Walters… - Rna, 2021 - rnajournal.cshlp.org
… (AngII) is a potent octapeptide hormone that binds to angiotensin II receptor type 1 (… the
mineralocorticoid aldosterone from cholesterol. The primary function of aldosterone is to regulate

Mineralocorticoid receptors, neuroinflammation and hypertensive encephalopathy

ME Brocca, L Pietranera, ER De Kloet… - Cellular and Molecular …, 2019 - Springer
function, because it binds and responds to glucocorticoids rather than to the natural
mineralocorticoid aldosterone. … salt appetite, since an additional angiotensin II antagonist is …

The role of lipid second messengers in aldosterone synthesis and secretion

SC Spaulding, WB Bollag - Journal of lipid research, 2022 - ASBMB
Aldosterone is the principal mineralocorticoid hormone … cortex, primarily in response to
angiotensin II (Ang II), elevated serum … electrolyte and fluid volume regulation and maintenance of …

Aldosterone Biosynthesis: Genetic Control and Contribution to the Development of Arterial Hypertension

BA Tkhorenko, AV Tsepokina, NN Trishkina… - Russian Journal of …, 2019 - Springer
functional implementation is the binding of aldosterone to the … converting enzyme (ACE)
is converted into angiotensin II. … of aldosterone, which binds to the mineralocorticoid receptor …

Interaction of vitamin D with peptide hormones with emphasis on parathyroid hormone, FGF23, and the renin-angiotensin-aldosterone system

N Latic, RG Erben - Nutrients, 2022 - mdpi.com
… D signaling in the regulation of cardiovascular function. One of the … to angiotensin II (AngII),
which then binds to angiotensin IIAldosterone binds to mineralocorticoid receptors and …

The intersection of mineralocorticoid receptor activation and the FGF23–Klotho cascade: a duopoly that promotes renal and cardiovascular injury

M Epstein, M Freundlich - Nephrology Dialysis Transplantation, 2022 - academic.oup.com
… had preserved renal function, the aldosterone levels were … to aldosterone revealed increased
fgf23 transcript levels via … suppress Klotho gene transcription include angiotensin II (Ang II), …

Mineralocorticoid receptor antagonists eplerenone and spironolactone modify adrenal cortex morphology and physiology

SS Pereira, L Carvalho, MM Costa, A Melo, IM Ferreira… - Biomedicines, 2021 - mdpi.com
regulatory activation of the RAAS with the possible increased angiotensin II secretion known
to stimulate aldosterone-… , exposure to two different MRAs drugs leads to functional and …