Facing the challenges of multidrug-resistant Acinetobacter baumannii: progress and prospects in the vaccine development

NA Mat Rahim, HY Lee, U Strych… - Human Vaccines & …, 2021 - Taylor & Francis
… of antibiotic resistance revealed that antibiotic resistance is … allowing for the rational design
of vaccines using a process known … 82,Citation86 antibiotic-resistant determinant-focused RV, …

Where are we and how far is there to go in the development of an Acinetobacter vaccine?

C Ma, W Chen - Expert Review of Vaccines, 2021 - Taylor & Francis
… by multidrug-resistant Acinetobacter baumannii are becoming … without the induction of drug
resistance and have a … and approaches used in the rational vaccine design, and the current …

[HTML][HTML] Confronting Tigecycline-Resistant Acinetobacter baumannii via Immunization Against Conserved Resistance Determinants

MH Chiang, YS Yang, JR Sun, YC Wang… - Frontiers in …, 2020 - frontiersin.org
… of immunization, the antibiotic resistance determinants used … We propose an immunization
approach using TGC resistance … We developed an alternative vaccine strategy targeting an …

Promising targets for immunotherapeutic approaches against Acinetobacter baumannii

SB de Freitas, DD Hartwig - Microbial Pathogenesis, 2022 - Elsevier
… multi-drug resistant (MDR) when they show resistance to three … use of OMVs as targets for
the development of immunization … and design, type of antibodies generated, and immunization

[HTML][HTML] Designing Multi-Antigen Vaccines Against Acinetobacter baumannii Using Systemic Approaches

MJ McConnell, AJ Martín-Galiano - Frontiers in Immunology, 2021 - frontiersin.org
Antimicrobial resistance in A. … genomes for bacterial pathogens has facilitated the rational
identification of antigens over reductionist and empirical approaches for vaccine/mAb design, a …

Acinetobacter baumannii subunit vaccines: recent progress and challenges

YT Lau, HS Tan - Critical reviews in microbiology, 2024 - Taylor & Francis
… the antibiotic resistancedesign to a more targeted approach using reverse vaccinology.
This review examined many recent subunit vaccine candidates for the highly antibiotic-resistant

In Silico Identification of Probable Drug and Vaccine Candidates Against Antibiotic-Resistant Acinetobacter baumannii

E Zadeh Hosseingholi, G Zarrini… - … Drug Resistance, 2020 - liebertpub.com
vaccine candidates. The outcome of this work will be helpful to find novel vaccine design
candidates and therapeutic targets for A. baumannii through experimental investigations. …

[HTML][HTML] A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins

…, Ş Ayaz-Güner, H Güner, G Dinç, A Ulu Kılıç… - Frontiers in …, 2022 - frontiersin.org
baumannii were captured using IgGs obtained from patient and … Results: Using the subtractive
proteomic approach, we … baumannii clinical isolates have extensive drug resistance, and …

New putative vaccine candidates against Acinetobacter baumannii using the reverse vaccinology method

S Fereshteh, S Abdoli, F Shahcheraghi, S Ajdary… - Microbial …, 2020 - Elsevier
… -drug resistance Acinetobacter baumannii are increasing worldwide. Discovery of the vaccine
against this … baumannii have been designed based on two aspects; the first group includes …

[HTML][HTML] Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches

…, ST Ashraf, M Shehroz, F Anwer, A Naz, A Ali - Scientific reports, 2021 - nature.com
… Due to the upsurge in antibiotic resistance mechanisms exhibited by A. baumannii, the
current … Seven of them were found to be non-toxic and have been used in vaccine design. The …