… -activating IgM is not required for primary antibody responses but promotes plasma cell differentiation and secondary antibody responses to a large particulate antigen …
AKE Palm, A Westin, D Ayranci, B Heyman - Frontiers in Immunology, 2024 - frontiersin.org
… B cell differentiation and opsonization of antigen. To facilitate detection of any differences,
we primed and boosted with a very low antigen dose (5x10 5 SRBC), used littermate controls, …
we primed and boosted with a very low antigen dose (5x10 5 SRBC), used littermate controls, …
BCR signaling in germinal center B cell selection
T Inoue, Y Baba, T Kurosaki - Trends in Immunology, 2024 - cell.com
… are required for GC responses as well as for pre-GC extrafollicular … into memory B cells or
plasma cells (text for references). … Binding to antigens triggers BCR signaling which regulates …
plasma cells (text for references). … Binding to antigens triggers BCR signaling which regulates …
B cell signaling in context
… into antibody-producing plasma cells (PCs) 10,11 . For these … aspects of B cell–T cell
interactions by regulating the levels of … drives rapid proliferation and extrafollicular differentiation. …
interactions by regulating the levels of … drives rapid proliferation and extrafollicular differentiation. …
[HTML][HTML] Restriction of memory B cell differentiation at the germinal center B cell positive selection stage
… B cells are primarily fated for GC expansion and plasma cell … MYC and MIZ1 form a module
that regulates GC B cell fate. … evaluated the binding of IgG1 antibodies in the serum of mice to …
that regulates GC B cell fate. … evaluated the binding of IgG1 antibodies in the serum of mice to …
Advances in understanding the formation and fate of B-cell memory in response to immunization or infection
L Kealy, KL Good-Jacobson - Oxford Open Immunology, 2021 - academic.oup.com
… TD antigen recognition, B cells will interact with CD4 + T cells… , c-Myb, which regulates the
responsiveness of plasma cells to the … to that of extrafollicular-derived B cells in systemic lupus …
responsiveness of plasma cells to the … to that of extrafollicular-derived B cells in systemic lupus …
Regulation of B cell responses by distinct populations of CD4 T cells
M Aloulou, N Fazilleau - biomedical journal, 2019 - Elsevier
… extra-follicular response whereas low BCR signal induces GC [15], [16], a phenomenon relying
on the correlation between … In addition, IL-9 produced by Tfh cells controls B cell progeny …
on the correlation between … In addition, IL-9 produced by Tfh cells controls B cell progeny …
B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus
C Wibrand, TR Wittenborn, LF Voss, G Winther… - Frontiers in …, 2023 - frontiersin.org
… that B cell intrinsic MHC haplotype governs their capacity for … other antigen-presenting
subsets such as dendritic cells and … as the main determinant of extrafollicular PB/PC activation vs…
subsets such as dendritic cells and … as the main determinant of extrafollicular PB/PC activation vs…
Integrin CD11b negatively regulates B cell receptor signaling to shape humoral response during immunization and autoimmunity
M Zhou, P Dascani, C Ding, JT Kos, D Tieri… - The Journal of …, 2021 - journals.aai.org
… and increases in Ag-specific germinal center B cells and plasma cells (PCs). Examination of
BCR … from GC B cells and extrafollicular B cells. The “choice” between these two maturation …
BCR … from GC B cells and extrafollicular B cells. The “choice” between these two maturation …
Plasma cells are formed in waning germinal centers via an affinity-independent process
HJ Sutton, BJ Parker, M Lofgren, C Dacon… - bioRxiv, 2023 - biorxiv.org
… Long-lived plasma cells (PCs) secrete antibodies that can … Cells that fail to bind antigen
and obtain T cell help will die … Cells that survive make a fate choice between continuing to …
and obtain T cell help will die … Cells that survive make a fate choice between continuing to …
[HTML][HTML] Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells
DYD Zhu, DP Maurer, C Castrillon, Y Deng… - bioRxiv, 2024 - ncbi.nlm.nih.gov
… primed for long-lived plasma cell differentiation in a vaccine … role of CD21 in regulating
efficient B cell proliferation 31 , 45 . … CD21 as an antigen receptor that initiates autoreactive B cell …
efficient B cell proliferation 31 , 45 . … CD21 as an antigen receptor that initiates autoreactive B cell …