… B cell differentiation and opsonization of antigen. To facilitate detection of any differences,
we primed and boosted with a very low antigen dose (5x10 5 SRBC), used littermate controls, …

… are required for GC responses as well as for pre-GC extrafollicular … into memory B cells or
plasma cells (text for references). … Binding to antigens triggers BCR signaling which regulates …

… into antibody-producing plasma cells (PCs) 10,11 . For these … aspects of B cell–T cell
interactions by regulating the levels of … drives rapid proliferation and extrafollicular differentiation. …

… B cells are primarily fated for GC expansion and plasma cell … MYC and MIZ1 form a module
that regulates GC B cell fate. … evaluated the binding of IgG1 antibodies in the serum of mice to …

… TD antigen recognition, B cells will interact with CD4 + T cells… , c-Myb, which regulates the
responsiveness of plasma cells to the … to that of extrafollicular-derived B cells in systemic lupus …

… extra-follicular response whereas low BCR signal induces GC [15], [16], a phenomenon relying
on the correlation between … In addition, IL-9 produced by Tfh cells controls B cell progeny …

… that B cell intrinsic MHC haplotype governs their capacity for … other antigen-presenting
subsets such as dendritic cells and … as the main determinant of extrafollicular PB/PC activation vs…

… and increases in Ag-specific germinal center B cells and plasma cells (PCs). Examination of
BCR … from GC B cells and extrafollicular B cells. The “choice” between these two maturation …

… Long-lived plasma cells (PCs) secrete antibodies that can … Cells that fail to bind antigen
and obtain T cell help will die … Cells that survive make a fate choice between continuing to …

… primed for long-lived plasma cell differentiation in a vaccine … role of CD21 in regulating
efficient B cell proliferation 31 , 45 . … CD21 as an antigen receptor that initiates autoreactive B cell …