… extrafollicular plasma cell and germinal center responses, in a CD4 + T-cell-dependent manner,
involving B cells with … Antigen affinity controls rapid T-dependent antibody production by …

… was similar to wild-type controls, but almost all of those … lived plasma cells, long-lived plasma
cells and memory cells. … -activated GC B cells did not impair extrafollicular B cell responses, …

… of plasma cells and production of class-switched antibodies … changes in signals regulating
GC processes. While some … in T cells collaborating with B cells at extrafollicular sites is also …

… that B-cells and antibodies can play both pro … cell vaccines and healthy controls (n=40)
were screened on a human protein microarray to detect IgG reactivities. Associations between …

… to self-ligands is regulated remains poorly understood. In this … role in regulating B cell TLR
signaling to self-antigens in mice… B cells, extrafollicular IgG2c-producing plasma cells, and …

… activation in the contexts of the extrafollicular response and … of signals including antigen
recognition by the B cell receptor (… Moreover, Cxcr4 signaling needs to be tightly regulated as a …

… B cells directly differentiate into extrafollicular plasma cells (PCs) and memory B cells (MBCs)
with unaltered antibodies, but … This is quite similar to what governs the extrafollicular PC …

… that regulate B-cell survival, division, and differentiation. B-… generation of plasma cells when
antigen is administered earlier … choices such as differentiation into antibody-secreting cells (…

… controls (Fig. 3j). In summary, MHCII-targeting of the antigen clearly increased antigen-specific
T- and B-cell … Finally, quantification of antigen-specific plasma cells in the bone marrow at …

… in the GCs are tightly regulated to ensure a strong humoral … affinity B cell clones specific for
the immunizing antigens while … , Tfh cells) and IL-21, while extrafollicular T cells in the T cell …