Delivery systems exploiting natural cell transport processes of macromolecules for intracellular targeting of Auger electron emitters

AA Rosenkranz, TA Slastnikova, GP Georgiev… - Nuclear Medicine and …, 2020 - Elsevier
… step-by-step delivery is the so-called modular nanotransporter, which … two decades ago, 111
In and 67 Ga delivered by anti-CD74 … of these agents as anti-cancer drugs including a DNA-…

Exploiting active nuclear import for efficient delivery of Auger electron emitters into the cell nucleus

AA Rosenkranz, TA Slastnikova… - … Journal of Radiation …, 2023 - Taylor & Francis
… This modular nanotransporter (MNT) approach recruits several systems of natural … with 111
In for radiotherapy in EGFR-overexpressing cancer. To improve the anticancer efficacy, they …

[HTML][HTML] Targeted radionuclide therapy using auger electron emitters: the quest for the right vector and the right radionuclide

MB Idrissou, A Pichard, B Tee, T Kibedi, S Poty… - Pharmaceutics, 2021 - mdpi.com
… NLS or TAT peptides for nuclear delivery. We found that NLS … modular nanotransporters
consist of a target-specific module… to Auger electrons is about 8.7 keV ( 125 I) and 5.4 keV ( 111

Auger Electron-Emitting Radionuclides in Radiopharmaceutical Therapy

KM Wulfmeier, J Cheng, IM Costa, A Rigby… - Radiopharmaceutical …, 2023 - Springer
… It decays to stable 111 Cd by electron capture with a half-life of 2.8 days, … modular
nanotransporters (MNTs) have also shown promise for the receptor-targeted delivery of AE emitters

[HTML][HTML] Platinum nanoparticles labelled with iodine-125 for combined “chemo-Auger electron” therapy of hepatocellular carcinoma

K Wawrowicz, K Żelechowska-Matysiak… - Nanoscale …, 2023 - pubs.rsc.org
emitters, there is a wide range of Auger electron emitters that can be applied in TRT. The most
commonly used AEs are radioactive indium (In; 111delivery of the high activities of Auger-…

[PDF][PDF] Basis research and development of DNA-targeted radio-platinum agents for Auger electron cancer therapy

尾幡穂乃香 - 2023 - eprints.lib.hokudai.ac.jp
… Iodine-123, 125, and In-111 have been commonly used in Auger electron therapy. Gallium-…
Antitumor activity of auger electron emitter 111In delivered by modular nanotransporter for …

[HTML][HTML] PARP-Targeted Radiotheranostics with Auger Electrons: An Updated Overview

L Filippi, L Urso, L Evangelista - Current Issues in Molecular Biology, 2024 - mdpi.com
… Consequently, given that indium-111 emits AEs, some investigations have been conducted
… conjugated with a radionuclide emitting particle exerting anti-tumor effects. Given that PARP-…

Advancements in the use of Auger electrons in science and medicine during the period 2015–2019

RW Howell - International journal of radiation biology, 2023 - Taylor & Francis
Antitumor efficacy was tested against PSMA + or PSMA − … modular nanotransporters (MNTs)
to direct Auger electron … They used this approach to deliver the Auger electron emitter 111 In …

[HTML][HTML] Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals

A Rigby, JE Blower, PJ Blower, SYA Terry… - Nuclear medicine and …, 2021 - Elsevier
… in which 201 Tl is manufactured and supplied, to thallium(III). Such a method would need
to be sufficiently mild to be used in the context of labelling sensitive biomolecules. The Tl(I)/Tl(…

[HTML][HTML] Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody

TS Karyagina, AV Ulasov, TA Slastnikova… - Frontiers in …, 2020 - frontiersin.org
Auger electron emitters, have great therapeutic potential that can be used to antitumor
In this study, we selected the Auger electron emitter 111 In as the cytotoxic agent, which has …