Delivery systems exploiting natural cell transport processes of macromolecules for intracellular targeting of Auger electron emitters
AA Rosenkranz, TA Slastnikova, GP Georgiev… - Nuclear Medicine and …, 2020 - Elsevier
… step-by-step delivery is the so-called modular nanotransporter, which … two decades ago, 111
In and 67 Ga delivered by anti-CD74 … of these agents as anti-cancer drugs including a DNA-…
In and 67 Ga delivered by anti-CD74 … of these agents as anti-cancer drugs including a DNA-…
Exploiting active nuclear import for efficient delivery of Auger electron emitters into the cell nucleus
AA Rosenkranz, TA Slastnikova… - … Journal of Radiation …, 2023 - Taylor & Francis
… This modular nanotransporter (MNT) approach recruits several systems of natural … with 111
In for radiotherapy in EGFR-overexpressing cancer. To improve the anticancer efficacy, they …
In for radiotherapy in EGFR-overexpressing cancer. To improve the anticancer efficacy, they …
[HTML][HTML] Targeted radionuclide therapy using auger electron emitters: the quest for the right vector and the right radionuclide
… NLS or TAT peptides for nuclear delivery. We found that NLS … modular nanotransporters
consist of a target-specific module… to Auger electrons is about 8.7 keV ( 125 I) and 5.4 keV ( 111 …
consist of a target-specific module… to Auger electrons is about 8.7 keV ( 125 I) and 5.4 keV ( 111 …
Auger Electron-Emitting Radionuclides in Radiopharmaceutical Therapy
KM Wulfmeier, J Cheng, IM Costa, A Rigby… - Radiopharmaceutical …, 2023 - Springer
… It decays to stable 111 Cd by electron capture with a half-life of 2.8 days, … modular
nanotransporters (MNTs) have also shown promise for the receptor-targeted delivery of AE emitters …
nanotransporters (MNTs) have also shown promise for the receptor-targeted delivery of AE emitters …
[HTML][HTML] Platinum nanoparticles labelled with iodine-125 for combined “chemo-Auger electron” therapy of hepatocellular carcinoma
K Wawrowicz, K Żelechowska-Matysiak… - Nanoscale …, 2023 - pubs.rsc.org
… emitters, there is a wide range of Auger electron emitters that can be applied in TRT. The most
commonly used AEs are radioactive indium (In; 111 … delivery of the high activities of Auger-…
commonly used AEs are radioactive indium (In; 111 … delivery of the high activities of Auger-…
[PDF][PDF] Basis research and development of DNA-targeted radio-platinum agents for Auger electron cancer therapy
尾幡穂乃香 - 2023 - eprints.lib.hokudai.ac.jp
… Iodine-123, 125, and In-111 have been commonly used in Auger electron therapy. Gallium-…
Antitumor activity of auger electron emitter 111In delivered by modular nanotransporter for …
Antitumor activity of auger electron emitter 111In delivered by modular nanotransporter for …
[HTML][HTML] PARP-Targeted Radiotheranostics with Auger Electrons: An Updated Overview
L Filippi, L Urso, L Evangelista - Current Issues in Molecular Biology, 2024 - mdpi.com
… Consequently, given that indium-111 emits AEs, some investigations have been conducted
… conjugated with a radionuclide emitting particle exerting anti-tumor effects. Given that PARP-…
… conjugated with a radionuclide emitting particle exerting anti-tumor effects. Given that PARP-…
Advancements in the use of Auger electrons in science and medicine during the period 2015–2019
RW Howell - International journal of radiation biology, 2023 - Taylor & Francis
… Antitumor efficacy was tested against PSMA + or PSMA − … modular nanotransporters (MNTs)
to direct Auger electron … They used this approach to deliver the Auger electron emitter 111 In …
to direct Auger electron … They used this approach to deliver the Auger electron emitter 111 In …
[HTML][HTML] Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals
… in which 201 Tl is manufactured and supplied, to thallium(III). Such a method would need
to be sufficiently mild to be used in the context of labelling sensitive biomolecules. The Tl(I)/Tl(…
to be sufficiently mild to be used in the context of labelling sensitive biomolecules. The Tl(I)/Tl(…
[HTML][HTML] Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody
TS Karyagina, AV Ulasov, TA Slastnikova… - Frontiers in …, 2020 - frontiersin.org
… Auger electron emitters, have great therapeutic potential that can be used to antitumor …
In this study, we selected the Auger electron emitter 111 In as the cytotoxic agent, which has …
In this study, we selected the Auger electron emitter 111 In as the cytotoxic agent, which has …