Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
… feature of the neurodegenerative diseases is apoptosis which is regulated by … apoptotic
mechanisms are involved in neurodegeneration. Abnormal levels of these molecular apoptotic

Copper dyshomeostasis in neurodegenerative diseasestherapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
… well as excitotoxic cell death and signaling cascades … therapeutic interventions based on
copper supplementation or removal in neurodegenerative diseases including Wilson’s disease

Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review

M Rekatsina, A Paladini, A Piroli, P Zis, JV Pergolizzi… - … in therapy, 2020 - Springer
neurodegeneration were identified. After presenting the most common neurodegenerative
diseases … information that could encourage the development of better therapeutic strategies. …

Regulated cell death: discovery, features and implications for neurodegenerative diseases

J Cui, S Zhao, Y Li, D Zhang, B Wang, J Xie… - Cell Communication and …, 2021 - Springer
… in neurodegenerative diseases. Here, we critically discuss the current knowledge of RCD,
including apoptosis, pyroptosis, autophagy-dependent cell death, … these cell death types to …

Apoptotic pathways and Alzheimer's disease: probing therapeutic potential

VK Sharma, TG Singh, S Singh, N Garg… - Neurochemical …, 2021 - Springer
… In neurodegenerative disorders, one of the major apoptosis counteractive pathways that
remain active is the phosphoinositol-3 kinase (PI3K)/Akt pathway. The AKT (v-Akt murine …

Apoptosis and apoptotic body: disease message and therapeutic target potentials

X Xu, Y Lai, ZC Hua - Bioscience reports, 2019 - portlandpress.com
… , retinal degeneration, transplant rejection, and neurodegenerative diseases are all caused
… the condition, at which this therapeutic effect may be mediated through induction of CXCL12 …

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

CT Chu - Neurobiology of disease, 2019 - Elsevier
… to important discoveries in neurodegenerative diseases, which … shared by most
neurodegenerative diseases. The landmark … emerged from studies of apoptotic pathways in …

Erythropoietin as a neuroprotective molecule: an overview of its therapeutic potential in neurodegenerative diseases

F Rey, A Balsari, T Giallongo, S Ottolenghi… - ASN …, 2019 - journals.sagepub.com
… imbalance, and cell death in these diseases. Multiple studies have … its neurotrophic action.
In some cases, clinical trials involving EPO have been performed, highlighting its therapeutic

Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues

S Kumari, R Dhapola, DHK Reddy - Apoptosis, 2023 - Springer
… By increasing the BAX/Bcl2 ratio, GSK-3β also encourages a mitochondrial pro-apoptotic
phenotype leading to neurodegenerative disease [71]. There are various evidence for role of …

[HTML][HTML] Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

R Tabassum, NY Jeong - International Journal of Medical Sciences, 2019 - ncbi.nlm.nih.gov
cell death, due to the production of free radicals in mitochondria. Neurodegenerative diseases
… neuronal cell death in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's …