The rise and fall of aspirin in the primary prevention of cardiovascular disease

I Raber, CP McCarthy, M Vaduganathan, DL Bhatt… - The Lancet, 2019 - thelancet.com
… trials of aspirin for the primary prevention of cardiovascular disease showed little … role of
aspirin in primary prevention of cardiovascular disease, contextualising … in men at increased risk. …

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

G Gelbenegger, M Postula, L Pecen, S Halvorsen… - BMC medicine, 2019 - Springer
… , an increased risk of major bleeding events under aspirin … from aspirin to the P2Y 12 receptor
inhibitor clopidogrel seems … an essential isoenzyme that converts clopidogrel into its active …

Rivaroxaban plus aspirin for the prevention of ischaemic events in patients with cardiovascular disease: a cost-effectiveness study

S Petersohn, X Pouwels, B Ramaekers… - … cardiology, 2020 - academic.oup.com
aspirin antiplatelet therapy in coronary artery disease, and additionally to clopidogrel antiplatelet
therapy in peripheral arterial diseaseprevention risk score (high score = higher risk of …

P2Y12 inhibitor versus aspirin monotherapy for secondary prevention of cardiovascular events: meta-analysis of randomized trials

D Aggarwal, K Bhatia, ZS Chunawala… - European heart …, 2022 - academic.oup.com
… was reported as low risk, some concern, or high risk. … aspirin with clopidogrel while 4
studies compared aspirin with ticagrelor. Six trials enrolled patients with coronary artery disease

P2Y12 inhibitors plus aspirin versus aspirin alone in patients with minor stroke or high-risk transient ischemic attack

ZX Li, Y Xiong, HQ Gu, M Fisher, Y Xian, SC Johnston… - Stroke, 2021 - Am Heart Assoc
… than aspirin alone for recurrent stroke prevention with a … search for aspirin plus clopidogrel
or aspirin plus ticagrelor … of stroke, MI, or cardiovascular disease (CVD) death.A, Myocardial …

Benefit and risks of aspirin in addition to ticagrelor in acute coronary syndromes: a post hoc analysis of the randomized GLOBAL LEADERS trial

M Tomaniak, P Chichareon, Y Onuma… - … cardiology, 2019 - jamanetwork.com
aspirin plus either clopidogrel (stable coronary artery disease… by 12 months of aspirin alone
in the prevention of the primary … sufficient efficacy in patients at high risk of ischemic events. …

Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome: the TICO …

BK Kim, SJ Hong, YH Cho, KH Yun, YH Kim, Y Suh… - Jama, 2020 - jamanetwork.com
prevention of cardiovascular disease, discontinuing aspirin while … Key exclusion criteria
included increased risk of bleeding … clopidogrel or prasugrel was used in the 8.2% of the patients

Efficacy and safety of rivaroxaban plus clopidogrel versus aspirin plus clopidogrel in patients with coronary atherosclerotic heart disease and gastrointestinal disease …

T Zhou, Y Gong, J Li, Y Wang, X Wang - Trials, 2023 - Springer
… as clopidogrel, also have an increased risk of GIB, but by a different mechanism from aspirin,
increasing the risk … a new strategy for the secondary prevention of CHD combined with GID …

Secondary prevention of antithrombotic therapy in patients with stable cardiovascular disease at high ischemic risk: a network meta-analysis of randomized controlled …

H Zhu, X Xu, H Wang, Q Chen, X Fang… - … in Cardiovascular …, 2023 - frontiersin.org
… of major bleeding to varying degrees, with ticagrelor plus aspirin associated with the highest
risk of major bleeding. The net clinical benefit favored clopidogrel or ticagrelor monotherapy…

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events

F Gragnano, D Cao, L Pirondini, A Franzone… - … College of Cardiology, 2023 - jacc.org
… compared with aspirin alone, albeit with a higher risk of major bleeding … of cardiovascular
events with clopidogrel monotherapy compared with aspirin in a heterogeneous patient cohort …