Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ …

M Suárez‐Calvet, TK Karikari, NJ Ashton… - EMBO molecular …, 2020 - embopress.org
… CSF p-tau biomarkers, phosphorylated at threonine-181 and … This study investigated
novel CSF and plasma p-tau … of the assays used in this study. We show the longest form of …

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective …

TK Karikari, TA Pascoal, NJ Ashton… - The Lancet …, 2020 - thelancet.com
… CSF tau phosphorylated at threonine 181 (p-tau181) is a highly … disease in both plasma
and serum. The blood p-tau181 … The blood p-tau181 assay described in this study could …

Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease

SD Chen, YY Huang, XN Shen, Y Guo, L Tan… - Translational …, 2021 - nature.com
… blood tau phosphorylated at threonine 181 (p-tau181) [3,4,5]. Recent researches have
shown promising results for plasma … Taken together, our analysis of longitudinal plasma p-tau181 …

Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease: a systematic review and meta-analysis

X Ding, S Zhang, L Jiang, L Wang, T Li… - Translational …, 2021 - Springer
… The lack of early diagnostic biomarkers for selecting prodromal or early-stage patients is one
of the roadblocks in clinical trials. The National Institute on Aging—Alzheimer’s Association …

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status

XN Shen, YY Huang, SD Chen, Y Guo, L Tan… - Translational …, 2021 - nature.com
… of plasma p-tau181 in the Braak I-IV ROI (AUC 0.86, 95%CI 0.80–0.92) which tends to represent
the early stage of tau … data but did not participate in the analysis or writing of this report. …

Development of a biosensor for phosphorylated Tau 181 protein detection in Early-Stage Alzheimer's disease

ME Schneider, L Guillade, MA Correa-Duarte… - …, 2022 - Elsevier
Tau species, particularly Tau fragments phosphorylated at threonine 181, these assays
electrodes for tau protein determination in plasma and brain tissues from Alzheimer patients …

Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology

NJ Ashton, TA Pascoal, TK Karikari, AL Benedet… - Acta …, 2021 - Springer
… capabilities of CSF p-tau at threonine 181 (p-tau181) [12] … quantification of phosphorylated
tau at threonine 231 in plasma and … Simoa assay presented in this study measures specific tau

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

C Clark, P Lewczuk, J Kornhuber, J Richiardi… - Alzheimer's research & …, 2021 - Springer
… Multivariate analysis assessed associations of plasma NfL and p-tau181 levels with AD, …
Neurofilament light (NfL) protein and tau phosphorylated at threonine 181 (p-tau181) are …

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient …

NR Barthélemy, RJ Bateman, C Hirtz, P Marin… - Alzheimer's research & …, 2020 - Springer
total and phosphorylated tau levels at threonine 181 (pT181) … the presence of amyloidosis
at an early stage in the disease. … could bias the estimation of the phosphorylation ratio at T217 …

Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment

J Chen, X Zhao, W Zhang, T Zhang, S Wu… - Alzheimer's Research & …, 2023 - Springer
Phosphorylated tau is believed to dissociate from dendrites and form neurofibrillary tangles
in the brains of AD patients. Tau protein phosphorylated at threonine 181 … Simoa assays. To …