PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors

MI Budzinska, D Villarroel-Campos… - Journal of cell …, 2020 - journals.biologists.com
… -D1 (BICD1), a dynein motor adaptor, as a key factor for … of BICD1, a cytoplasmic dynein
adaptor previously found to be … PTPN23 may promote the association between the trafficking …

[HTML][HTML] The Rab11-regulated endocytic pathway and BDNF/TrkB signaling: Roles in plasticity changes and neurodegenerative diseases

G Moya-Alvarado, MV Guerra, R Tiburcio, E Bravo… - Neurobiology of …, 2022 - Elsevier
… In this review, we briefly discuss the organization of the endocytic … Cytoplasmic dynein (or
dynein 1, referred to as dynein) is the … of neurotrophins and neurotrophin receptors continue …

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

MA Olenick, R Dominguez, ELF Holzbaur - Journal of Cell Biology, 2019 - rupress.org
association with cargo-specific effectors efficiently regulates … Cytoplasmic dynein 1 (referred
to in this study as dynein) is a … , we expressed the neurotrophic receptor TrkB-RFP and GFP-…

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

G Moya-Alvarado, R Tiburcio-Felix, MR Ibáñez… - Elife, 2023 - elifesciences.org
receptor B (TrkB) and the p75 neurotrophin receptor (p75) are the primary regulators of
dendritic growth in the CNS. After being bound by BDNF, TrkB and … motors, such as cytoplasmic

Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport

OM Lazo, G Schiavo - Elife, 2023 - elifesciences.org
… new regulator of neurotrophin receptor trafficking and signaling… the cytoplasmic dynein motor
complex, which mediates the … experiments showed that JIP3 and JIP4 association to Rab10 …

Role of dynein–dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis

A Tempes, J Weslawski, A Brzozowska… - Journal of …, 2020 - Wiley Online Library
… Research on mammalian neurons has shown that the unique organizationmotor to maturing
late endosomes, amphisomes, or autophagosomes resulted in a decrease in TrkB receptor

PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling

G Moya-Alvarado, X Valero-Peña… - Frontiers in Molecular …, 2024 - frontiersin.org
TrkB is endocytosed in axons and retrogradely transported to the cell body by the
molecular motor dynein. In the cell body, activated TrkB upregulates CREB, increasing the …

Investigating the mechanisms regulating retrograde transport and signalling of neurotrophin receptors in neuronal cells

MI Budzinska - 2019 - discovery.ucl.ac.uk
… Recently, our laboratory demonstrated that the dynein motor … by cytoplasmic dynein
complex; and Trk receptors can directly … The association of TrkA and TrkB with Rab11-recycling …

BDNF/TrkB mediates long-distance dendritic growth by activating CREB/PI3K-mTOR-dependent translation in neuronal cell bodies

G Moya-Alvarado, FC Bronfman - bioRxiv, 2020 - biorxiv.org
neurotrophic factor (BDNF) and its receptors tyrosine kinase receptor B (TrkB) and the p75
neurotrophin receptor (p75) … After being bound by BDNF, TrkB and p75 are endocytosed into …

[HTML][HTML] BDNF-dependent modulation of axonal transport is selectively impaired in ALS

AP Tosolini, JN Sleigh, S Surana, ER Rhymes… - Acta Neuropathologica …, 2022 - Springer
… factor (BDNF) on in vivo axonal transport in different α-motor neuron (MN) … in neurotrophin
receptors were confined to the synapse, we evaluated the synaptic expression of total TrkB