[HTML][HTML] Interleukin-5 in the pathophysiology of severe asthma

C Pelaia, G Paoletti, F Puggioni, F Racca… - Frontiers in …, 2019 - frontiersin.org
… and eotaxins were found in induced sputum from patients experiencing acute asthma
exacerbations (… Binding interactions of human interleukin 5 with its receptor α subunit. Large scale …

The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis

H Nagase, S Ueki, S Fujieda - Allergology International, 2020 - jstage.jst.go.jp
… for severe asthma (Table 1) In our analysis, approximately 25% of patients with severe asthma
… We classified the patients with severe asthma (n ¼ 102) into four phenotypes based on …

[HTML][HTML] Study of serum interleukin 5 level and factors that impact on this level in Iraqi asthmatic children

RM Hameed, HAAN Abood, MM Ahmed… - Biomedical and …, 2019 - journals.lww.com
… , and immunological parameters of asthmatic children in interleukin-5 levels Further, in this
study, there was a significant difference in the IL-5 level in asthma patients depending on sex, …

[HTML][HTML] Role of cytokines in EGPA and the possibility of treatment with an anti-IL-5 antibody

T Isozaki, T Homma, H Sagara, T Kasama - Journal of Clinical Medicine, 2020 - mdpi.com
… is insufficient, the anti-interleukin-5 antibody mepolizumab can be … mediator of allergic
asthma and induces IL-5 and eotaxin/CCL11 … These associations led to the speculation that the …

[HTML][HTML] Severe eosinophilic asthma

A Bakakos, S Loukides, P Bakakos - Journal of clinical medicine, 2019 - mdpi.com
… stem cells and specialized CD34 + interleukin-5 receptor (IL-5R… single eotaxin-1 or eotaxin-2
KO mice and both eotaxin 1 and … European Respiratory Society/American Thoracic Society (…

[HTML][HTML] Treatment challenges in severe eosinophilic asthma: differential response to anti-IL-5 and anti-IL-5R therapy

A Bakakos, N Rovina, P Bakakos - International Journal of Molecular …, 2021 - mdpi.com
… It is clinically important to underline that eotaxin-1 cannot mobilize … since eotaxin-1 alone
can only lead to blood eosinophilia but not to tissue infiltration. On the contrary, blocking eotaxin

[HTML][HTML] IL-5 antagonism reverses priming and activation of eosinophils in severe eosinophilic asthma

J Luo, W Chen, W Liu, S Jiang, Y Ye, R Shrimanker… - Mucosal …, 2024 - Elsevier
… Expression of chemokine receptors in eosinophils and interleukin-5 levels in patients was not
… No significant difference was detected in eotaxin concentrations in EA, although eotaxin-2 …

Two cases of dupilumab-associated eosinophilic pneumonia in asthma with eosinophilic chronic rhinosinusitis: IL-5-driven pathology?

Y Nishiyama, T Koya, K Nagano, S Abe… - Allergology …, 2022 - jstage.jst.go.jp
… vascular cell adhesion protein 1 (VCAM-1), eotaxin, and periostin, which are strongly involved
in the … In both cases as previously reported,1 CCL26 (eotaxin-3) and periostin significantly …

Molecular markers of type 2 airway inflammation are similar between eosinophilic severe asthma and eosinophilic chronic obstructive pulmonary disease

M Fricker, VM McDonald, NA Winter, KJ Baines… - Allergy, 2021 - Wiley Online Library
… production of eosinophil chemokines including eotaxins CCL11 and CCL24. … severe asthma
vs mild to moderate and non-asthma controls; however similar to our study, no association

Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases

HK Kandikattu, SU Venkateshaiah, A Mishra - Cytokine & growth factor …, 2019 - Elsevier
… of allergic diseases including asthma, dermatitis and various … by cytokine interleukin-5 (IL-5)
and the eotaxin chemokines. … helminth infection chronic asthma and allergic diseases and …