[HTML][HTML] Molecular targets for biological therapies of severe asthma

C Pelaia, C Crimi, A Vatrella, C Tinello… - Frontiers in …, 2020 - frontiersin.org
… Respiratory Society (ERS) and American Thoracic Society (ATS) … such as eotaxins (49).
Furthermore, in patients with T2-high … and interleukin-5 expression in subjects with asthma. Am J …

IL‐5 receptor expression in lung fibroblasts: Potential role in airway remodeling in asthma.

K Bajbouj, R AbuJabal, L Sahnoon, R Olivenstein… - Allergy, 2023 - search.ebscohost.com
… Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics con…
model of atopic asthma: suppression by dexamethasone or anti- interleukin- 5 antibody. Am …

[HTML][HTML] Eosinophilic chronic obstructive pulmonary disease

JC Weissler, TN Adams - Lung, 2021 - Springer
… is the expression of a dimeric receptor for interleukin-5 (IL-5). … as RANTES (CCL5) and
eotaxin (CCL11), help differentiate … , the association of poorer outcomes in eosinophilic asthma

Significant improvement in lung function and asthma control after benralizumab treatment for severe refractory eosinophilic asthma

F Menzella, P Ruggiero, C Galeone, C Scelfo… - Pulmonary …, 2020 - Elsevier
… key cytokines involved in the pathophysiology of eosinophilic asthma is interleukin-5 (IL-5), …
and persistence of eosinophils into airways, such as eotaxin-2 and 3, thymic stromal …

Immune modulatory effects of novel monoclonal antibodies target therapies in severe eosinophilic asthma patients

L Bergantini - 2020 - usiena-air.unisi.it
… A cohort of 28 patients affected by severe eosinophilic asthma were treated with anti IL-5
drugs: 20 … found in most cases of severe asthma and in asthma with severe exacerbations. It …

[HTML][HTML] Novel biological therapies for severe asthma endotypes

C Pelaia, G Pelaia, C Crimi, A Maglio, AA Stanziola… - Biomedicines, 2022 - mdpi.com
… directed against immunoglobulins E (IgE), interleukin-5 (IL-5) and its … eotaxin [73]. Furthermore,
in patients with type 2 … when itepekimab was administered in association with dupilumab. …

[HTML][HTML] Activated sputum eosinophils associated with exacerbations in children on mepolizumab

GE Wilson, J Knight, Q Liu, A Shelar, E Stewart… - Journal of Allergy and …, 2024 - Elsevier
asthma exacerbations. This study included 290 children with severe, exacerbation-prone
asthma, and the authors concluded that mepolizumab reduced asthma exacerbations by 27% …

[HTML][HTML] Eosinophil lineage-committed progenitors as a therapeutic target for asthma

BM Salter, X Ju, R Sehmi - Cells, 2021 - mdpi.com
… Moderate to severe asthmatics (>3% sputum; >300 cells/µL … a significant reduction in
exacerbations, serum eotaxin, and … not show any reduction in asthma exacerbation; thus, the use …

High transcriptional activity and clinical correlations in eosinophils of patients with late-onset asthma

TY Lin, CY Lo, PJ Chang, YL Lo, CS Lee… - Journal of Asthma …, 2023 - Taylor & Francis
… in early-onset asthma (EOA) differ from those in late-onset asthma (LOA). Clinical trials of
anti-interleukin-5 (IL-5) treatment for severe eosinophilic asthma showed a better response for …

IL-5 Exposure In Utero Increases Lung Nerve Density and Airway Reactivity in Adult Offspring

KM Lebold, MG Drake, LB Hales-Beck… - American journal of …, 2020 - atsjournals.org
… Eosinophils are actively recruited to nerves via neuronal release of eotaxin (17), and
physically adhere to nerves by binding ICAM (18). In a study of adults who died of fatal asthma, …