Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications

V Varadhan, MS Manikandan, A Nagarajan… - … -Research and Practice, 2024 - Elsevier
… Additionally, small RNA molecules can modulate ATMATM mutations. Furthermore, the
design and interpretation of clinical studies assessing TOP1 inhibitors, PARPi (Poly-ADP ribose

Sensors and Inhibitors for the detection of ataxia telangiectasia mutated (ATM) protein kinase

C Huang, NR Filippone, T Reiner… - Molecular …, 2021 - ACS Publications
… The role of ATM signaling in the DDR has been widely … of its cousins, poly-ADPribose
polymerase (PARP) and ataxia … meant to identify novel compounds with radiosensitizing …

ATM in DNA repair in cancer

MH Jin, DY Oh - Pharmacology & therapeutics, 2019 - Elsevier
poly (ADP-ribose) polymerase (PARP), ataxia telangiectasia, … critical role in chromatin structure
modulation. Furthermore, it … in ATM signaling pathways to control ATM's activity. Although …

Pharmacologic inhibition of ataxia telangiectasia and Rad3‐related (ATR) in the treatment of head and neck squamous cell carcinoma

P Karukonda, D Odhiambo… - Molecular …, 2022 - Wiley Online Library
… -resistance, and modulate the immune microenvironment in … exist between the ATM and ATR
signaling pathways, these … evaluated AZD6738 with the poly-ADP ribose polymerase (PARP…

[HTML][HTML] Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer

C Gulliver, R Hoffmann, GS Baillie - … journal of biochemistry & cell biology, 2022 - Elsevier
… The recent success of Poly (ADP-ribose) polymerase (PARP) … The in-depth roles of ATM
and ATR signalling pathways in … Conversely, another potential approach to modulate ATM

Therapeutic Options Targeting the Ataxia-Telangiectasia Mutated (ATM)-mediated DNA Damage Response, Macropinocytosis, and Adaptive Immunity in Ovarian …

CC Tseng, MH Ku, YC Wu, WL Huang… - Anticancer …, 2024 - ar.iiarjournals.org
… the regulatory role of ATM in modulating macropinocytosis, a … a repair complex and transfers
ADP-ribose to target proteins to … transmitting them to downstream signaling pathways (71). …

[HTML][HTML] The hallmarks of aging in Ataxia-Telangiectasia

J Aguado, C Gómez-Inclán, HC Leeson… - Ageing Research …, 2022 - Elsevier
… Notably, it was suggested that ATM also phosphorylates and modulates the activity of key …
wide epigenetic changes in AT have provided novel advances in our understanding of how AT …

The Role of the DNA Damage Response in Ataxia-Telangiectasia Syndrome

A Ribes-Zamora - Neurodevelopment and Neurodevelopmental …, 2019 - books.google.com
… coordination of all pathways involved. Some of the most important direct ATM targets are
CHK2 and p53, two downstream effectors that modulate pivotal DDR pathways like cell cycle …

Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand

L Mei, J Zhang, K He, J Zhang - Journal of hematology & oncology, 2019 - Springer
… progressed through poly ADP-ribose polymerase inhibitors. … ) is a complex interconnected
signaling network that is essential to … ATM knock out mice have a similar ataxia telangiectasia

Ataxia telangiectasia and Rad3-related protein inhibitors

A Sahu, P Sahu, V Asati, SK Sahu, J Mishra - Current Molecular Targets of …, 2024 - Elsevier
… with an increasing number of novel ATR inhibitors are assessed … 2.5, we have summarized
the ATM signaling network. … DNA break caused either through poly(ADP-ribose) polymerase (…