Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
… inhibitory NLGN3 R451C-mutant neurons, we identified differentially … between a hippocampal
and cortical environment, which … whether the NLGN3 R451C mutation alters the function of …
and cortical environment, which … whether the NLGN3 R451C mutation alters the function of …
An autism-associated neuroligin-3 mutation affects developmental synapse elimination in the cerebellum
ESK Lai, H Nakayama, T Miyazaki… - Frontiers in neural …, 2021 - frontiersin.org
… association between the R451C mutation in NLGN3 and … GluN2B subunits in the hippocampus.
Given NLGN3 is localized … In Tsc2 mutant mice, the density of dendritic spines in cortical …
Given NLGN3 is localized … In Tsc2 mutant mice, the density of dendritic spines in cortical …
Neuroligin-3: a circuit-specific synapse organizer that shapes normal function and autism spectrum disorder-associated dysfunction
M Uchigashima, A Cheung, K Futai - Frontiers in Molecular …, 2021 - frontiersin.org
… transmission in the hippocampal CA1 region without any changes in presynaptic release …
In layer 2/3 pyramidal neurons of the somatosensory cortex, Nlgn3-R451C KI mice show …
In layer 2/3 pyramidal neurons of the somatosensory cortex, Nlgn3-R451C KI mice show …
Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies
FAE Yacoubi, M Oukabli, A Ibrahimi… - CNS & Neurological …, 2024 - ingentaconnect.com
… Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical
synaptic function. Proc Natl Acad Sci 2011; 108(33): 13764-9. http://dx.doi.org/10.1073/pnas.…
synaptic function. Proc Natl Acad Sci 2011; 108(33): 13764-9. http://dx.doi.org/10.1073/pnas.…
Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations
… changes in neuronal circuits involved in cognitive functions. This hypothesis was tested in
mice carrying the human R451C mutation of Nlgn3 gene (NLG3 R451C … somatosensory cortex…
mice carrying the human R451C mutation of Nlgn3 gene (NLG3 R451C … somatosensory cortex…
Altered Caecal Neuroimmune Interactions in the Neuroligin-3R451C Mouse Model of Autism
… the impact of the neuroligin-3 R451C mutation on both the enteric nervous system and the
immune responses within the caecum, experiments should investigate changes in mucus …
immune responses within the caecum, experiments should investigate changes in mucus …
Environmental enrichment modulates affiliative and aggressive social behaviour in the neuroligin-3 R451C mouse model of autism spectrum disorder
… Environmental enrichment differentially modulates anxiety in NL3 R451C and WT mice. A) …
that environmental enrichment was able to alter the NL3 R451C mouse social phenotype, …
that environmental enrichment was able to alter the NL3 R451C mouse social phenotype, …
Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the …
… ATX treatment affected the odds of correct responses differently between WT and NL3 R451C
… Taken together, while the autism-related NL3 R451C gene mutation did not alter attention …
… Taken together, while the autism-related NL3 R451C gene mutation did not alter attention …
NMDA receptor hypofunction underlies deficits in parvalbumin interneurons and social behavior in neuroligin 3 R451C knockin mice
… Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical …
we hypothesize that NMDARs might be the link between NL3 R451C mutation and PV+ …
we hypothesize that NMDARs might be the link between NL3 R451C mutation and PV+ …
Neuroligins and neurodevelopmental disorders: X-linked genetics
TA Nguyen, AW Lehr, KW Roche - Frontiers in Synaptic Neuroscience, 2020 - frontiersin.org
… Taken together, the NLGN3 R451C mutation differentially alter synaptic function depending
… expressed NLGNs in heterologous cells or rat hippocampal neurons. What the role is for …
… expressed NLGNs in heterologous cells or rat hippocampal neurons. What the role is for …