[HTML][HTML] Cellular and synaptic dysfunctions in Parkinson's disease: stepping out of the striatum
N Mallet, L Delgado, M Chazalon, C Miguelez… - Cells, 2019 - mdpi.com
… are autonomous pacemakers, their spiking activity is instead independent of excitatory inputs
[… Together with the EPN, the SNr is one of the output nuclei in the basal ganglia. Like other …
[… Together with the EPN, the SNr is one of the output nuclei in the basal ganglia. Like other …
Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
… of synaptic inputs [8]; these autonomous pacemaking action … [53], as increased demand
for Ca 2+ handling exacerbates … the frequency of autonomous pacemaking action potentials …
for Ca 2+ handling exacerbates … the frequency of autonomous pacemaking action potentials …
Mechanism of pacemaker activity in zebrafish DC2/4 dopaminergic neurons
… resistance, and continual, cell-autonomous pacemaker activity, that strengthen the basis for
… currents, suggesting that synaptic inputs to these cells in the intact CNS can modulate their …
… currents, suggesting that synaptic inputs to these cells in the intact CNS can modulate their …
Modeling the pathophysiology of Parkinson's disease in patient-specific neurons
J Feng - Experimental Biology and Medicine, 2021 - journals.sagepub.com
… and relaxation of skeletal muscles needed for the intended … in the basal ganglia are
autonomous pacemakers. Principal … bursts of spontaneous excitatory post-synaptic currents …
autonomous pacemakers. Principal … bursts of spontaneous excitatory post-synaptic currents …
[HTML][HTML] A Network-Level Stochastic Model for Pacemaker GABAergic Neurons in Substantia Nigra Pars Reticulata
K Guimarães, A Duarte - Mathematics, 2023 - mdpi.com
… of output from the sensorimotor basal ganglia. Experimental data … of synaptic input are
referred to as autonomous spiking … neuron (Neuron 1) which spikes regardless of any excitatory …
referred to as autonomous spiking … neuron (Neuron 1) which spikes regardless of any excitatory …
[图书][B] Prostheses for the Brain: Introduction to Neuroprosthetics
… Neuronal excitation Propagation of excitation Dynamic … of parts of the basal ganglia with
frequencies greater than 120 … A pacemaker autonomously generates electric pulses at high …
frequencies greater than 120 … A pacemaker autonomously generates electric pulses at high …
[HTML][HTML] Symmetric and Asymmetric Synapses Driving Neurodegenerative Disorders
D Romaus-Sanjurjo, A Custodia, M Aramburu-Núñez… - Symmetry, 2021 - mdpi.com
… In excitatory synapses, LTP is induced only when both pre- … amount of DA to the basal
ganglia (BG) and forebrain [21]. … , STN neurons lose their autonomous pacemaking due to both …
ganglia (BG) and forebrain [21]. … , STN neurons lose their autonomous pacemaking due to both …
[HTML][HTML] An Agent-Based Model to Reproduce the Boolean Logic Behaviour of Neuronal Self-Organised Communities through Pulse Delay Modulation and …
L Irastorza-Valera, JM Benítez, FJ Montáns… - Biomimetics, 2024 - mdpi.com
… for patients with implants or pacemakers, limiting its applications… , neurons behave in an
autonomous, unsupervised and … [32], but they are out of phase anyway, and so they have to be …
autonomous, unsupervised and … [32], but they are out of phase anyway, and so they have to be …
[HTML][HTML] Connectivity and functionality of the globus pallidus externa under normal conditions and Parkinson's disease
… of complex connections with the other basal ganglia nuclei and brain regions. Recently, …
in an autonomous manner, which makes their spiking activity independent of excitatory inputs (…
in an autonomous manner, which makes their spiking activity independent of excitatory inputs (…
[HTML][HTML] The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism
… -excitation and opto-inhibition) to dissect the specific functional contribution of key cortico-basal
ganglia (… First, STN neurons have autonomous pacemaker firing properties 44 , and there …
ganglia (… First, STN neurons have autonomous pacemaker firing properties 44 , and there …