The multifaceted role of flavonoids in cancer therapy: leveraging autophagy with a double-edged sword

Z Zhang, J Shi, EC Nice, C Huang, Z Shi - Antioxidants, 2021 - mdpi.com
autophagy, suggesting that combining autophagy inhibitors … therapy and the related
mechanisms involved in autophagy … an understanding of the modulation of autophagy (Figure 2). …

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

SM Lim, EA Mohamad Hanif, SF Chin - Cell & Bioscience, 2021 - Springer
… , disease stage and external stimuli. Recently, the emerging role of autophagy as a double-edged
sword in … The therapeutic potential of autophagy modulation has been contentious and …

Autophagy is a doubleedged sword in the therapy of colorectal cancer

B Zhang, L Liu - Oncology Letters, 2021 - spandidos-publications.com
Autophagy can either stimulate tumor survival or induce … This ‘double-edged sword’ role of
autophagy in colorectal cancer is … In conclusion, autophagy is considered a novel therapeutic

Chaperone-Mediated Autophagy in Brain Injury: A Double-Edged Sword with Therapeutic Potentials

H Zhang, Y Tian, S Ma, Y Ji, Z Wang, P Xiao… - Molecular …, 2024 - Springer
… We also discuss the potential of CMA as a therapeutic target to treat brain injury and provide
… We also discuss the potential of developing CMA-targeted therapeutic strategies for treating …

[HTML][HTML] Autophagy-driven NETosis is a double-edged sword–review

X Liang, L Liu, Y Wang, H Guo, H Fan, C Zhang… - Biomedicine & …, 2020 - Elsevier
… , and reviews the role of autophagy-driven NETosis in various diseases, in the hope that this
autophagy and NETs and discuss the role of autophagy-driven NETosis in related diseases. …

[PDF][PDF] The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword. Antioxidants 2021, 10, 1138

Z Zhang, J Shi, EC Nice, C Huang, Z Shi - 2021 - academia.edu
… for cancer therapy and the related mechanisms involved in autophagy to … on an understanding
of the modulation of autophagy (Figure 2). … The therapeutic potential of apigenin. Int. J. …

The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity

R Chavez-Dominguez, M Perez-Medina… - Frontiers in …, 2020 - frontiersin.org
Autophagy in cancer cells is considered a double-edged sword since, in initial stages of …
Second, activation of autophagy in response to cancer therapy potentially leads to tumors …

[HTML][HTML] Autophagy in regulatory T cells: a double-edged sword in disease settings

J Zhang, L Chen, F Xiong, S Zhang, K Huang… - Molecular …, 2019 - Elsevier
… Unfortunately, although Treg adoptive transfer after SCT manifests a therapeutic potential
to promote tolerance, the low frequency of Tregs, time required to expand them in vitro to …

[HTML][HTML] Autophagy, a double-edged sword for oral tissue regeneration

X Xu, J Wang, Y Xia, Y Yin, T Zhu, F Chen… - Journal of Advanced …, 2024 - Elsevier
… to fully harness the therapeutic potential of autophagy in oral tissue regeneration. Overall,
this review offers a comprehensive overview of the current state of autophagy research in oral …

The peroxisome-autophagy redox connection: a double-edged sword?

H Li, C Lismont, I Revenco, MAF Hussein… - Frontiers in Cell and …, 2021 - frontiersin.org
… concepts of (selective) autophagy, we critically examine … possible relationships among
peroxisome functioning, cellular H 2 O 2 levels, and autophagic signaling in health and disease. …