Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration
Y Lyu, AV Tschulakow, K Wang… - Proceedings of the …, 2023 - National Acad Sciences
… by excited states such as formed by melanin chemiexcitation initiated by the combination
of … the cDNA for tyrosinase, the rate-limiting enzyme in the melanin synthesis pathway, is …
of … the cDNA for tyrosinase, the rate-limiting enzyme in the melanin synthesis pathway, is …
Melanin-binding colorants: Updating molecular modeling, staining and labeling mechanisms, and biomedical perspectives
JC Stockert, J Espada, A Blázquez-Castro - Colorants, 2022 - mdpi.com
… of spiral melanin units could be formed by aggregation of … found in classical tissue
histochemistry give metachromatic reactions, … ), whole body autoradiography has shown labeling …
histochemistry give metachromatic reactions, … ), whole body autoradiography has shown labeling …
Melanogenesis is directly affected by metabolites of melatonin in human melanoma cells
JKS Möller, K Linowiecka, M Gagat… - International journal of …, 2023 - mdpi.com
… subjected compounds on tyrosinase activity using amelanotic … of decreased TYR activity
and melanin synthesis. In parallel, … level is dependent on the formation of melanosomes, which …
and melanin synthesis. In parallel, … level is dependent on the formation of melanosomes, which …
Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium—an explanation for the …
Y Lyu, AV Tschulakow, U Schraermeyer - BioRxiv, 2022 - biorxiv.org
… However, transfection with tyrosinase led to a reduction in the … from all mice were enucleated
and prepared for histology. … show that melanin is associated with TLMs and lipofuscin. …
and prepared for histology. … show that melanin is associated with TLMs and lipofuscin. …
Neuromelanin modulates heterocyclic aromatic amine-induced dopaminergic neurotoxicity
… We characterized melanin from Sepia officinalis and … in the presence of tyrosinase enzyme
can lead to neuromelanin … cells at 48 h, demonstrating the formation of melanin in TYR SH-…
can lead to neuromelanin … cells at 48 h, demonstrating the formation of melanin in TYR SH-…
Investigation of the role of melanosomes and radicals in photoreceptor disc clearance by the retinal pigment epithelium
Y Lyu - 2023 - tobias-lib.ub.uni-tuebingen.de
… Tyrosinase-induced newly formed melanosomes show NIR-… with tyrosinase cDNA induces
RPE melanosome formation and … Tyrosinase is the rate-limiting enzyme in melanin synthesis. …
RPE melanosome formation and … Tyrosinase is the rate-limiting enzyme in melanin synthesis. …
Increased PHGDH expression promotes aberrant melanin accumulation
… Histological examination of skin tissue from PHGDH tetO … The membrane was washed,
then exposed to autoradiography … , we performed qPCR for tyrosinase, a melanocyte marker, …
then exposed to autoradiography … , we performed qPCR for tyrosinase, a melanocyte marker, …
The skin-color is associated with its physiological state: A case study on a colorful variety, hybrid grouper (Epinephelus fuscoguttatus× Epinephelus lanceolatus)
K Zhou, K Zhang, X Fan, W Zhang, Y Liang, X Wen… - Aquaculture, 2022 - Elsevier
… China) and autoradiography. Chemiluminescent detection … melanin production pathway
affects the fish skin color variation. In the tyrosine metabolic pathway, the expression and activity …
affects the fish skin color variation. In the tyrosine metabolic pathway, the expression and activity …
[PDF][PDF] Biomedical overview of melanin. 2. Updating molecular modeling, synthesis mechanism, and supramolecular properties regarding melanoma therapy
JC Stockert, A Blázquez-Castro - Biocell, 2022 - cdn.techscience.cn
… In human melanosomes, melanin appears as formed by a … of melanin is limited to
Stages III–IV, but tyrosinase activity is … be histochemically detected by tyrosinase assays (Angeletti …
Stages III–IV, but tyrosinase activity is … be histochemically detected by tyrosinase assays (Angeletti …
Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone
… Autoradiographic images of brain slices were digitized on an … reconstructed from 57 digitized
autoradiograms (voxel size: … the analysis of rodent autoradiographic cerebral blood flow 68 …
autoradiograms (voxel size: … the analysis of rodent autoradiographic cerebral blood flow 68 …