… antibody responses in humoral immunity. We consider … subclasses affiliated with type 1 or
type 2 T cell responses, as … spleen or lymph node and B-cell enriched follicles. What follows is …

… studied for their role and function in the humoral immune system. … BCR-specific antigen leads
to B cell activation and proliferation, … encoded PAMP receptors (T-cell independent). PAMP …

… the most important B-cell subsets and their role in the … are essential to the generation of
short- and long-lived humoral … The data suggest that B RM cells are an important component of …

… , and outline gaps in knowledge and important areas of inquiry. … effects of IL-12 on humoral
immunity in humans and whether … responses to T-independent type II Ags. Patients with TACI …

… Type II T-independent (TI-II) antigens contain highly repetitive … important to understand the
mechanisms of how TI antigens … By using genetic models that prevent GC formation in a B cell–…

… T cell dependent or T cell independent, usually starts quickly … to mount an effective humoral
immune response. Some B … short-lived, plays an important role in vaccine biology. Firstly, …

… However, the mechanism of B cell activation by TI-II antigens remains unclear. In this
study, we … An important component of humoral immunity is the production of antigen-specific …

… components of B cell activation upon TI antigen stimulation and … (28, 29), we evaluated TI
type II immune responses to investigate … that InsP 6 plays an essential role in BCR signaling by …

… B cell activation plays an important role … humoral immune response, using B cell-specific
Fcrl5 transgenic (Fcrl5 Tg) mice. In T cellindependent type 2 (TI2) responses induced by antigen …

… in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B
cell … with T-cell-independent antigen TNP-LPS, results showed that compared with wild-…