… PCR by routine probes, and (if not tested at diagnosis) would give the false impression that
a patient may be in complete molecular … deeper molecular responses and targeting the CML …

… bullet against cancer”), RQ-PCR showed that the reduction of the BCR-… -PCR, but it is always
susceptible to the specific assay design, pre-PCR processing and molecular dropout (target …

… of therapeutic strategies aimed specifically at inhibiting this … of 32 of 33 BCR::ABL1 mutants
tested, the exception being … BCR::ABL1 molecular abnormality detected by FISH or PCR (…

… on a 3% agarose gel for detection of the BCR-ABL1 transcript. As controls for multiplex … of
plasmid dilutions for every atypical BCR-ABL1 transcript was amplified within the PCR. Beta-…

… % of tumor cells) is referred to as a major molecular response … effectiveness evaluation
guiding to targeted therapy and TKIs … For this, the digital PCR approach described in this paper is …

… Molecular diagnosis and measurement of minimal residual … therapy molecular tests including
BCR-ABL1 transcript … to the quantity of the target, that is, BCR-ABL1 , in the starting sample. …

… (TKIs) therapy targets BCR‑ABL1 positive cells and induces … quantified by digital PCR and
tested in several laboratories. … This could be useful in countries where molecular diagnostics …

… the development of therapeutic strategies aimed specifically at … FISH and PCR are used as
complementary diagnostic tests … BCRABL1 molecular abnormality detected by FISH or PCR (…

… duplex ddPCR assay using the Europe against Cancer (EAC… -protein kinase ABL1 (BCR-ABL1)
and ABL1 and compared … Subsequently, we aimed to compare the M-BCR-ABL1 …

… Targeting BCR::ABL1 and BCL-2 could have therapeutic … The BCR: ABL1 TKIs transformed
CML from a fatal cancer … An important question is the variability of PCR testing results and the …