Genome-wide screening of m6A-modified transcript in the Wilms' tumor

Z Liu, F He, J Liu, S OuYang, Z Li, Y Li, F Ma, H Chang… - 2021 - researchsquare.com
… In the present study, we provide the rst transcriptome-wide m6A pro le of nephroblastoma. …
, and PTEN, were analyzed by quantitative real-time PCR (qRT-PCR). Brie y, total RNA was …

Bayesian statistical learning for big data biology

C Yau, K Campbell - Biophysical reviews, 2019 - Springer
individual cells. However, the challenge when working with single cells is the inherent sensitivity
of cells … A related analysis is identifying differential splicing in which exon usage varies …

Comprehensive Characterization of RNA Editing in Primary Gastric Adenocarcinoma through RNA-seq Data Analysis

J Behroozi, S Shahbazi, MR Bakhtiarizadeh… - 2020 - researchsquare.com
… RNA editing sites at the transcriptome-wide level in gastric cancer… and alternative splicing of
hematopoietic cell phosphatase (… of largesized single cells. Scienti c reports. 2018;8(1):1-11. …

N6-methyladenosine-mediated changes in SOCS3 expression regulate skeletal muscle stem cell senescence

M Zhu, C Lian, G Chen, P Zou, B gang Qin - 2022 - researchsquare.com
… Dysfunctions in RNA splicing, translation and degradation … were used to evaluate
transcriptome-wide m6A in young and … Brie y, the cultured cells were washed twice with PBS and …

Characterization of clinically relevant RNA alterations for personalized cancer medicine

JL Trincado Alonso - 2019 - tdx.cat
… consists of the study of associations between genotypes and splicing variation. Splicing
quantitative trait locus (sQTL) analysis is a useful approach to discover genetic alterations …

Impact of Rare Non-coding Variants on Human Diseases through Alternative Polyadenylation Outliers

L Li, X Zou, Z Zhao, Y Chen, K Xiong, Z Wang, S Chen… - 2024 - researchsquare.com
… identi ed as expression outlier or splicing outlier genes (ie, … Brie y, for genotype data, we
rst removed sites marked as "… by alternative polyadenylation transcriptome-wide association …

Polymorphism in maternal HLA-DRB5 is associated with the risk of preeclampsia in Chinese population

C Xu, L Zhou, Q Fang, Y Liu, J Yang, L Luo, S Li, P Guo… - 2023 - researchsquare.com
… information and sQTL curating splicing-related information. S-… Brie y, the PE cases and
healthy controls were randomly … expression data and transcriptome-wide disease association …

Nuclear PKM2 promotes pre-mRNA processing by binding folded RNA G-quadruplexes

D Anastasakis, M Apostolidi, J Rinehart, M Hafner - 2022 - researchsquare.com
… gene regulation on a transcriptome-wide level using loss- and gain-… sites and that 3.) we did
not observe systematic splicing changes in … Brie y, 10 × 15 cm plates at 70% con uency cells

Serotonin limits generation of chromaffin cells during adrenal organ development

P Kameneva, VI Melnikova, ME Kastriti… - Nature …, 2022 - nature.com
cells (both conditions combined) using Smart-seq2 technology, which allows an extraordinary
deep sequencing of individual cells (7000/8000 genes per cell on … in differential splicing of …

Characterisation of APOBEC3B-Mediated RNA Editing in Breast Cancer Cells Reveals Regulatory Roles of NEAT1 and MALAT1 lncRNAs

P Clarke, C Zhang, Y Lu, M Wang, B Chen, F Xiong… - 2023 - researchsquare.com
… the identi cation of transcriptome-wide A3B-mediated RNA editing sites and their cellular or
… We interpreted this as a re ection of the dynamic nature of A3B action, where A3B brie y binds…