… Although certain behaviors have been identified as altered in Sx c – null mutant mice, our
understanding of the comprehensive impact of Sx c – on behavior remains incomplete. …

… safety of targeting system x c − . In this study we chronically treated system x c − - deficient
mice and their … and/or stress reaction of mice of both genotypes, and thus independent of its …

… Next, we assessed brain function in male genetically modified rats (MSxc) created to … ,
locomotor activity, or behaviors reliant on simple learning. However, MSxc rats exhibited deficits in …

… In xCT knockout mice, PSNPI were decreased compared to those in … mice. Moreover,
TNF-α and IL-1β expression in wildtype mice was increased after LPS treatment, but inhibited in …

… observed in the transgenic mice lacking xCT or in sulfasalazine-treated mice is mediated
by a … phenotype in the absence of system x c − . These findings suggest that drugs targeting …

… system. To do this, we developed a novel rat strain that lacks functional Sxc (Figure 2-1B,
MSxc rat)… With this tool, we tested the hypothesis that global removal of Sxc in a rat would …

… mice naturally null for SLC7a11 (SLC7a11 sut/sut mice) – the gene the encodes for the substrate
specific light chain for system … of SLC7a11 sut/sut mice was revealed 48 h following PTI …

… in wild-type NMRI (Naval Medical Research Institute) mice as well as the effects of acute
pharmacological Sxc inhibition on acute seizures evoked after post-SE epileptogenesis. …

… -treated xCT−/− mice. Together, these data underscore the relevance of targeting system
xc − in NP but call for the development of more specific inhibitors to mitigate potential side …

… us to differentiate the glutamate uptake supported by system x c – or by high-affinity … inhibitors.
The specificity was further demonstrated in primary astrocyte cultures from transgenic mice …