Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model

R Soudy, R Kimura, A Patel, W Fu, K Kaur… - Scientific Reports, 2019 - nature.com
amylin (hAmylin)-induced depression of hippocampal … activity at the amylin receptor and
mediate their beneficial effects… the disruption of hippocampal long term potentiation observed in …

The importance of understanding amylin signaling mechanisms for therapeutic development in the treatment of Alzheimer's disease

S Servizi, RR Corrigan… - Current pharmaceutical …, 2020 - ingentaconnect.com
… suggested amylin binding in the hippocampus [83, 87-89]. … to be mediated through the
TRPV4 receptor; as TRPV4 receptor … shares neurotoxic properties with Abeta42 in long-term

An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?

M Sciaccaluga, A Megaro, G Bellomo… - International Journal of …, 2021 - mdpi.com
… induce NGFR -mediated neuronal death through the p75 neurotrophin receptor, which is
a … NMDA-dependent long term potentiation (LTP) induction in the hippocampal CA1 and …

Amylin and amylin receptors in Alzheimer's disease

W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
Long-term potentiation (LTP) is a process involving persistent … felt to be mediated by neuronal
amylin receptors, a notion … , cAC253, to amylin receptors within the hippocampus. These in …

Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro

R Soudy, R Kimura, W Fu, A Patel, J Jhamandas - Plos one, 2022 - journals.plos.org
… Aβ oligomer-mediated long term potentiation (LTP) impairment in mouse hippocampal slices
[… Effects of AMY3 EVs on Aβ-induced depression of hippocampal long term potentiation (LTP…

Genetic depletion of amylin/calcitonin receptors improves memory and learning in transgenic Alzheimer's disease mouse models

A Patel, R Kimura, W Fu, R Soudy, D MacTavish… - Molecular …, 2021 - Springer
… to human amylin- and Aβ-induced depression of hippocampal long-term potentiation (LTP) …
of these target receptors for Aβ could attenuate the amyloid-induced neuroinflammation, …

[HTML][HTML] Amylin signaling in diabetes and Alzheimer's disease: therapy or pathology?

J Grizzanti, R Corrigan, S Servizi… - Journal of neurology & …, 2019 - ncbi.nlm.nih.gov
Amylin is known to affect long-term potentiation (LTP) in the … Low concentrations to of
human amylin evoke a Ca 2+ response that is mediated through its native receptor. However, at …

Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology

K Sharma, S Pradhan, LK Duffy, S Yeasmin… - International Journal of …, 2021 - mdpi.com
… , including long-term depression (LTD), long-term potentiation (… receptors mediate Aβ induced
neurotoxicity in hippocampal … ) and human amylin on hippocampal long-term potentiation (…

Survey of CNS Expression of the Amylin Receptor in Health and Metabolic Disease: Potential Relevance to Alzheimer's Disease

SJ Servizi - 2019 - search.proquest.com
… and leptin signaling has been shown to enhance long-term potentiation (… Beta amyloidinduced
depression of hippocampal long-term potentiation is mediated through the amylin receptor

Neuroprotective effects of the amylin analog, pramlintide, on Alzheimer's disease are associated with oxidative stress regulation mechanisms

S Patrick, R Corrigan, J Grizzanti… - Journal of …, 2019 - content.iospress.com
… ability of amylin to activate downstream TRPV4 receptors and … Pramlintide reduces H 2 O 2
-mediated endogenous oxidative … in Aβ plaque burden in the hippocampus but not the cortex. …