Short amylin receptor antagonist peptides improve memory deficits in Alzheimer's disease mouse model
… amylin (hAmylin)-induced depression of hippocampal … activity at the amylin receptor and
mediate their beneficial effects… the disruption of hippocampal long term potentiation observed in …
mediate their beneficial effects… the disruption of hippocampal long term potentiation observed in …
The importance of understanding amylin signaling mechanisms for therapeutic development in the treatment of Alzheimer's disease
S Servizi, RR Corrigan… - Current pharmaceutical …, 2020 - ingentaconnect.com
… suggested amylin binding in the hippocampus [83, 87-89]. … to be mediated through the
TRPV4 receptor; as TRPV4 receptor … shares neurotoxic properties with Abeta42 in long-term …
TRPV4 receptor; as TRPV4 receptor … shares neurotoxic properties with Abeta42 in long-term …
An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?
M Sciaccaluga, A Megaro, G Bellomo… - International Journal of …, 2021 - mdpi.com
… induce NGFR -mediated neuronal death through the p75 neurotrophin receptor, which is
a … NMDA-dependent long term potentiation (LTP) induction in the hippocampal CA1 and …
a … NMDA-dependent long term potentiation (LTP) induction in the hippocampal CA1 and …
Amylin and amylin receptors in Alzheimer's disease
W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
… Long-term potentiation (LTP) is a process involving persistent … felt to be mediated by neuronal
amylin receptors, a notion … , cAC253, to amylin receptors within the hippocampus. These in …
amylin receptors, a notion … , cAC253, to amylin receptors within the hippocampus. These in …
Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro
R Soudy, R Kimura, W Fu, A Patel, J Jhamandas - Plos one, 2022 - journals.plos.org
… Aβ oligomer-mediated long term potentiation (LTP) impairment in mouse hippocampal slices
[… Effects of AMY3 EVs on Aβ-induced depression of hippocampal long term potentiation (LTP…
[… Effects of AMY3 EVs on Aβ-induced depression of hippocampal long term potentiation (LTP…
Genetic depletion of amylin/calcitonin receptors improves memory and learning in transgenic Alzheimer's disease mouse models
A Patel, R Kimura, W Fu, R Soudy, D MacTavish… - Molecular …, 2021 - Springer
… to human amylin- and Aβ-induced depression of hippocampal long-term potentiation (LTP) …
of these target receptors for Aβ could attenuate the amyloid-induced neuroinflammation, …
of these target receptors for Aβ could attenuate the amyloid-induced neuroinflammation, …
[HTML][HTML] Amylin signaling in diabetes and Alzheimer's disease: therapy or pathology?
J Grizzanti, R Corrigan, S Servizi… - Journal of neurology & …, 2019 - ncbi.nlm.nih.gov
… Amylin is known to affect long-term potentiation (LTP) in the … Low concentrations to of
human amylin evoke a Ca 2+ response that is mediated through its native receptor. However, at …
human amylin evoke a Ca 2+ response that is mediated through its native receptor. However, at …
Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology
… , including long-term depression (LTD), long-term potentiation (… receptors mediate Aβ induced
neurotoxicity in hippocampal … ) and human amylin on hippocampal long-term potentiation (…
neurotoxicity in hippocampal … ) and human amylin on hippocampal long-term potentiation (…
Survey of CNS Expression of the Amylin Receptor in Health and Metabolic Disease: Potential Relevance to Alzheimer's Disease
SJ Servizi - 2019 - search.proquest.com
… and leptin signaling has been shown to enhance long-term potentiation (… Beta amyloidinduced
depression of hippocampal long-term potentiation is mediated through the amylin receptor…
depression of hippocampal long-term potentiation is mediated through the amylin receptor…
Neuroprotective effects of the amylin analog, pramlintide, on Alzheimer's disease are associated with oxidative stress regulation mechanisms
S Patrick, R Corrigan, J Grizzanti… - Journal of …, 2019 - content.iospress.com
… ability of amylin to activate downstream TRPV4 receptors and … Pramlintide reduces H 2 O 2
-mediated endogenous oxidative … in Aβ plaque burden in the hippocampus but not the cortex. …
-mediated endogenous oxidative … in Aβ plaque burden in the hippocampus but not the cortex. …