Drug Targeting to the Lung: Chemical and Biochemical Considerations
PA Crooks, NR Penthala… - Pharmaceutical …, 2019 - taylorfrancis.com
… The pulmonary endothelial cell barrier is relatively permeable … Thus, in the rat, within 20
minutes of inhalation of radiolabeled … HNE inhibitor, showed selective inhibition of lung HNE and …
minutes of inhalation of radiolabeled … HNE inhibitor, showed selective inhibition of lung HNE and …
β-Arrestin–biased allosteric modulator potentiates carvedilol-stimulated β adrenergic receptor cardioprotection
… exercise-induced heart rate and the nonselective inhibition of both β 1 adrenergic receptor
(… effects in other tissues, such as bronchial and blood vessel constriction (Cleland et al., 2000)…
(… effects in other tissues, such as bronchial and blood vessel constriction (Cleland et al., 2000)…
Pharmacologic treatments for acute respiratory distress syndrome
N Qadir, SY Chang - Critical care clinics, 2021 - criticalcare.theclinics.com
… tested, including those targeting ventilatorassociated lung injury (VALI), dead space ventilation,
inflammation, alveolar epithelial and capillary endothelial injury, and dysfunctional fluid …
inflammation, alveolar epithelial and capillary endothelial injury, and dysfunctional fluid …
Acute respiratory distress syndrome novel therapies
K Ma, K Patel, M Naddour, A Virani… - Critical Care Nursing …, 2019 - journals.lww.com
… This is thought to be secondary to acid in the lungs causing platelet-neutrophil interactions
… pulmonary vascular permeability, a major characteristic of ARDS. Increased permeability …
… pulmonary vascular permeability, a major characteristic of ARDS. Increased permeability …
Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with …
S Zeng, M Nishihama, L Weldemichael, H Lozier… - BMC Pulmonary …, 2024 - Springer
… In lungs, inhalation of albuterol and other β2-agonists are thought to mainly affect airway
smooth muscle cells and have a bronchodilatory effect, although effects on other lung cells (…
smooth muscle cells and have a bronchodilatory effect, although effects on other lung cells (…
Diacylglycerol Kinase is a Keystone Regulator of Signaling Relevant to the Pathophysiology of Asthma
MA Hernandez-Lara, J Richard… - … of Physiology-Lung …, 2024 - journals.physiology.org
… One group designed DGKγ-specific inhibitor and by radiolabeling and positron emission
536 tomography (PET) scans traced the molecule to cross the blood brain barrier and bind 537 …
536 tomography (PET) scans traced the molecule to cross the blood brain barrier and bind 537 …
[PDF][PDF] Siyang Zeng1, 2, 3, Melissa Nishihama2, 3, Lemlem Weldemichael2, 3, Helen Lozier2, 3, 4, Warren M. Gold3 and
M Arjomandi - bmcpulmmed.biomedcentral.com
… Beta2-adrenoceptor agonists as inhibitors of lung vascular permeability to radiolabelled
transferrin in the adult respiratory distress syndrome in man. Eur J Nucl Med. 1986;12(8):381–4. …
transferrin in the adult respiratory distress syndrome in man. Eur J Nucl Med. 1986;12(8):381–4. …
Pharmacological and genetic approaches to modulate energy metabolism in skeletal muscle cells
C Skagen - 2022 - duo.uio.no
… by a combination of functional studies using radiolabelled substrates with gene expression
… active activators and inhibitors. In paper I, the well-studied β2-AR agonist terbutaline was …
… active activators and inhibitors. In paper I, the well-studied β2-AR agonist terbutaline was …
The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca2+-handling system in heartin pathophysiological conditions
AG Guevorkian - Heliyon, 2020 - cell.com
Atthe Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic
peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and …
peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and …
[HTML][HTML] Polyethylenimine (PEI) in gene therapy: Current status and clinical applications
J Casper, SH Schenk, E Parhizkar, P Detampel… - Journal of Controlled …, 2023 - Elsevier
… The potential of nucleic acid therapeutics is almost limitless, as it allows for a broad spectrum
of applications including inhibition of pathological protein production (ie, gene silencing), …
of applications including inhibition of pathological protein production (ie, gene silencing), …