[PDF][PDF] Hepatitis C virus E2 envelope glycoprotein induces an immunoregulatory phenotype in macrophages

YC Kwon, K Meyer, G Peng, S Chatterjee, DF Hoft… - …, 2019 - Wiley Online Library
Binding between HCV E2 and CD81 inhibits host immune response, including T-cell, B-cell,
or natural killer (NK) cells… -function analysis of hepatitis C virus envelope-CD81 binding. J …

[HTML][HTML] The influence of hepatitis C viral loads on natural killer cell function

M Collister, C Ellison, Q Li, GY Minuk… - Gastroenterology …, 2019 - ncbi.nlm.nih.gov
… , HCV envelope 2 protein can directly impair NK cell cytotoxic … IL-2 induced IFN-γ synthesis
through binding of cognate CD81virus can indirectly restrict NK cell activation by inhibiting

Galectin-9 and Interferon-Gamma Are Released by Natural Killer Cells upon Activation with Interferon-Alpha and Orchestrate the Suppression of Hepatitis C Virus …

…, U Perricone, G Iannolo, G Russelli, C Carcione… - Viruses, 2022 - mdpi.com
… act extracellularly to inhibit HCV binding to host cells and … predicted the binding of HCV
envelope protein E2 to galectin-9 … NK-cell signaling molecules such as CD81 by viral proteins [73]…

Immunomodulation of the natural killer cell phenotype and response during HCV infection

GF Njiomegnie, SA Read, N Fewings, J George… - Journal of clinical …, 2020 - mdpi.com
cell activation is inhibitedcells in chronic hepatitis C (CHC) patients, as well as dampened
cytotoxic and IFN-γ responses [69]. Binding of the HCV glycoprotein E2 to CD81 on NK cells

[PDF][PDF] Hepatitis C virus manipulates humans as its favorite host for a long‐term relationship

RB Ray, R Ray - Hepatology, 2019 - Wiley Online Library
… epitope outside the CD81 binding site of the E1/E2 complex displays … Hepatitis C virus
impairs natural killer cell-mediated … Hepatitis C virus inhibits CD4 T cell function via binding to …

Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?

MH Razizadeh, A Zafarani… - Cell Communication and …, 2023 - Springer
… , the hepatitis C virus (HCV) … role in the lysis of influenza-infected cells through binding to
hemagglutinin (HA) [78]. The previous data has shown that HCMV, via its pp65 protein, inhibits

Immunopathogenesis of liver injury during hepatitis C virus infection

M Irshad, P Gupta, K Irshad - Viral Immunology, 2019 - liebertpub.com
… Increased natural killer cell cytotoxicity and NKp30 … against hepatitis C virus infection in
high-risk individuals and inhibitsBinding of hepatitis C virus envelope protein E2 to CD81 up…

The role of natural killer cell killer immunoglobulin-like receptors in the development and treatment of hepatocellular carcinoma

JA Coad - 2023 - eprints.soton.ac.uk
… development in patients with hepatitis C. I then aimed to … immune tolerance through inhibition
of dendritic cell function via … such as CD9, CD63 and CD81 can be used to extract specific …

Characterization of functional determinants in the C-terminal part of hepatitis C virus E1 glycoprotein ectodomain

R Moustafa - 2019 - theses.hal.science
… Besides, HCV E2 and NS5A proteins have been shown to bind to PKR … E2 or HCV virions
on a support can inhibit NK cells effector functions and IFN-γ production by crosslinking CD81

Hepatitis C virus infection: host–virus interaction and mechanisms of viral persistence

DGI Chigbu, R Loonawat, M Sehgal, D Patel, P Jain - Cells, 2019 - mdpi.com
… an inhibition of innate immune cells such as dendritic cell (DC) and natural killer (NK) cells
by HCV viral proteins, … The binding of HCV E2 proteins to CD81 on NK cells was shown to be …