… Besides, HCV E2 and NS5A proteins have been shown to bind to PKR … E2 or HCV virions
on a support can inhibit NK cells effector functions and IFN-γ production by crosslinking CD81 …

… Modulation of Natural Killer Cell Response Natural killer (NK) cells are a large proportion of
the … Our study revealed that HCV E2 envelope glycoprotein suppresses C3 expression and …

… Natural Killer (NK) cells have a pivotal role in innate immune … the viral E2 protein that, by
binding to NK cell-CD81 receptor, … This cytokine stimulates the secretion of transforming growth …

… The acute phase of hepatitis C virus (HCV) infection is … been shown to be inhibited by nAbs
targeting CLDN1 or CD81 or SR-… The portion of E2 protein that binds to the host proteins is …

… T cell responses persists in acute hepatitis C virus infection … modifications which can inhibit
NK cell anti-viral immunity. … cells and natural killer cells in patients with chronic hepatitis …

… , CD63, CD81 and CD82), a superfamily of proteins characterized … to hepatitis C virus (HCV)
of about 50 nm, and HIV or SARS … by B cells inhibit T and natural killer (NK) cell proliferation, …

… the E2-CD81 interaction can promote T-helper cell functions … the function of immunity-related
cells by binding with CD81 (7… a modified sE2 antigen inhibiting CD81 binding induces an …

… equilibrium between MMPs and their inhibitors (tissue inhibitors of MMPs, TIMPs) is … stress
and activates circulating cytotoxic natural killer (NK) cells, key actors of … NK natural killer cell …

… in individuals suffering from advanced viral hepatitis C [134]. … , the E2-CD81 association
was demonstrated to expose E2 … activity that inhibits T-cell functions in viral infection [163]. …

… by binding to CD81, SR-B1, and/or heparin sulfate on the cell … E2 is a viral envelope
glycoprotein that forms a heterodimer … of HCV infection and inhibition of T-cell function. Results of …