[HTML][HTML] A hepatitis C virus DNA vaccine encoding a secreted, oligomerized form of envelope proteins is highly immunogenic and elicits neutralizing antibodies in …

MG Masavuli, DK Wijesundara, A Underwood… - Frontiers in …, 2019 - frontiersin.org
… the function of critical non-structural (NS) HCV proteins … of E2 with CD81 by binding to the
regions of E2 that form the … the sera to inhibit binding of genotype 1b HCV VLPs to Huh7 cells. …

[HTML][HTML] Innate and adaptive immunopathogeneses in viral hepatitis; crucial determinants of hepatocellular carcinoma

MYW Zaki, AM Fathi, S Samir, N Eldafashi, KY William… - Cancers, 2022 - mdpi.com
Natural killer (NK) cells also release TNFα, which binds to the … inhibit effector T cell function
and enhance Treg cell function … homozygous genes encoding killer cell immunoglobulin-like …

HLA-E* 01: 01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E* 01: 03 allele increases the resistance to anti-HCV …

E Hosseini, ES Kazerooni, A Azarkeivan, Z Sharifi… - Human Immunology, 2022 - Elsevier
… has shown that binding of HCV-derived core protein peptide, … responses due to less inhibition
of NK cell function. So far, … frequent blood transfusions to hepatitis C virus (HCV) infection, …

IL-26 inhibits hepatitis C virus replication in hepatocytes

É Beaumont, V Larochette, L Preisser, C Miot… - Journal of …, 2022 - Elsevier
… , 8 natural killer (NK) cells 8 and some non-immune cells (such … involved in viral entry (CLDN1,
SCARB1, CD81, OCLN, … on its ability to bind viral RNA and inhibit its replication. The …

[HTML][HTML] Association of NK Cells with the Severity of Fibrosis in Patients with Chronic Hepatitis C

A Kleczka, B Mazur, K Tomaszek, A Gabriel, R Dzik… - Diagnostics, 2023 - mdpi.com
… TGFβ proteinsstimulates the cytotoxic effect of NK cells on … CD81 on the surface of natural
killer cells, the E2 envelope … in the percentage of natural killer cells and their subtypes in …

Roles of natural killer cell receptors and adaptors in anti-tumor and anti-virus immunity

R Li - 2022 - escholarship.mcgill.ca
functions to escape from NK cellmediated viral clearance. … cells express envelope glycoprotein
E2 that binds CD81, … of NK cells and the binding of its ligands stimulates the cytotoxicity …

Immune mechanisms of viral clearance and disease pathogenesis during viral hepatitis

C Ferrari, V Barili, S Varchetta… - The liver: biology and …, 2020 - Wiley Online Library
… Moreover, NK and natural killer T (NKT) cells are uniquely enriched in the liver, their … that
HCV is able to inhibit NK cells by interaction between the E2 protein and CD81 [226, 227] and …

Multifunctional role of exosomes in viral diseases: From transmission to diagnosis and therapy

P Chaudhari, V Ghate, M Nampoothiri, S Lewis - Cellular signalling, 2022 - Elsevier
… such as CD9, CD63, CD81. These tetraspanins participate in … Globally 142 million people
suffer from chronic hepatitis C … by inhibiting T-cell activation and increasing natural killer cell

CD81 (Cluster of Differentiation 81)

S Hasterok, B Nyesiga… - Atlas of Genetics and …, 2020 - opus.us.edu.pl
functions and mechanisms regulated by the CD81 protein in … binding appears to modulate
CD81 activity in cells, signifying … hepatitis C virus envelope protein (E)2 interacts with cellular

[HTML][HTML] A review of hepatitis B virus and hepatitis C virus immunopathogenesis

C Saraceni, J Birk - Journal of Clinical and Translational …, 2021 - ncbi.nlm.nih.gov
… that natural killer (NK) cells and natural killer T (NKT) cellsvirus particles and exposes
the CD81 cell membrane protein … Essentially, T cell function is inhibited and their cytotoxic …